Version history

{
  "scope": "mouse E13 MGE (medial ganglionic eminence) interneuron progenitors",
  "claim_text": "PV and SST interneuron identities emerge from common MGE progenitors through differential opening of chromatin at distal regulatory elements, with MEF2C showing both common and subtype-specific binding patterns.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41586-021-03933-1",
    "claim": "PV and SST interneuron identities emerge from common MGE progenitors through differential opening of chromatin at distal regulatory elements, with MEF2C showing both common and subtype-specific binding patterns.",
    "evidence": "scRNA-seq, scATAC-seq, and multiomic (dual RNA/ATAC) sequencing on E13 MGE revealed early chromatin signatures of interneuron identity, with MEF2C CUT&RUN showing PV-specific binding sites.",
    "effect_size": "more loci specifically bound by MEF2C in PV cells compared to SST",
    "text_access": "fulltext",
    "study_system": "mouse E13 MGE (medial ganglionic eminence) interneuron progenitors",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Generic interneuron features are first detected upon cell cycle exit through the opening of chromatin at distal elements.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "This work revealed both common and subtype-specific binding of MEF2C, with more loci specifically bound in PV cells compared to SST."
  },
  "section_id": "section_02_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json",
  "effect_size": "more loci specifically bound by MEF2C in PV cells compared to SST",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-02",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-1c4a74c94c96"
  ],
  "source_span": "Generic interneuron features are first detected upon cell cycle exit through the opening of chromatin at distal elements.",
  "study_system": "mouse E13 MGE (medial ganglionic eminence) interneuron progenitors",
  "evidence_refs": [
    {
      "ref": "paper:paper-1c4a74c94c96"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "scRNA-seq, scATAC-seq, and multiomic (dual RNA/ATAC) sequencing on E13 MGE revealed early chromatin signatures of interneuron identity, with MEF2C CUT&RUN showing PV-specific binding sites.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-02",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}