Version history

{
  "scope": "mouse cortex callosal corticocortical pathways",
  "claim_text": "Channelrhodopsin-2-assisted circuit mapping (CRACM) introduced in 2007 enabled the first synapse-level, cell-type-specific dissection of long-range callosal projections in mouse cortical slices, demonstrating that contralateral cortico-cortical (callosal) excitatory inputs target specific postsynaptic cortical pyramidal cell types with sub-cellular spatial resolution.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nn1891",
    "claim": "Channelrhodopsin-2-assisted circuit mapping (CRACM) introduced in 2007 enabled the first synapse-level, cell-type-specific dissection of long-range callosal projections in mouse cortical slices, demonstrating that contralateral cortico-cortical (callosal) excitatory inputs target specific postsynaptic cortical pyramidal cell types with sub-cellular spatial resolution.",
    "cite_key": "Petreanu2007",
    "evidence": "In-utero or virally-mediated ChR2 expression in callosally-projecting cortical neurons, followed by optical photostimulation paired with whole-cell recording in mouse cortical slices.",
    "effect_size": "qualitative — methodological advance enabling cell-type-resolved long-range corticocortical connectivity mapping",
    "text_access": "abstract_only",
    "study_system": "mouse cortex callosal corticocortical pathways",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1038/nn.2538",
      "10.7554/eLife.66836"
    ],
    "effect_size_source_sentence": "Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — methodological advance enabling cell-type-resolved long-range corticocortical connectivity mapping",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:987379eb-ecdd-42eb-818f-383280a8fca9"
  ],
  "source_span": "Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections",
  "study_system": "mouse cortex callosal corticocortical pathways",
  "evidence_refs": [
    {
      "ref": "paper:987379eb-ecdd-42eb-818f-383280a8fca9"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "In-utero or virally-mediated ChR2 expression in callosally-projecting cortical neurons, followed by optical photostimulation paired with whole-cell recording in mouse cortical slices.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}