- claim_text
Channelrhodopsin-2-assisted circuit mapping (CRACM) introduced in 2007 enabled the first synapse-level, cell-type-specific dissection of long-range callosal projections in mouse cortical slices, demonstrating that contralateral cortico-cortical (callosal) excitatory inputs target specific postsynaptic cortical pyramidal cell types with sub-cellular spatial resolution.
- raw_fields
{
"n": 0,
"doi": "10.1038/nn1891",
"claim": "Channelrhodopsin-2-assisted circuit mapping (CRACM) introduced in 2007 enabled the first synapse-level, cell-type-specific dissection of long-range callosal projections in mouse cortical slices, demonstrating that contralateral cortico-cortical (callosal) excitatory inputs target specific postsynaptic cortical pyramidal cell types with sub-cellular spatial resolution.",
"cite_key": "Petreanu2007",
"evidence": "In-utero or virally-mediated ChR2 expression in callosally-projecting cortical neurons, followed by optical photostimulation paired with whole-cell recording in mouse cortical slices.",
"effect_size": "qualitative — methodological advance enabling cell-type-resolved long-range corticocortical connectivity mapping",
"text_access": "abstract_only",
"study_system": "mouse cortex callosal corticocortical pathways",
"argument_role": "supporting",
"replication_status": "independently_replicated",
"claim_source_sentence": "Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [
"10.1038/nn.2538",
"10.7554/eLife.66836"
],
"effect_size_source_sentence": "Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections"
}- source_refs
[
"paper:987379eb-ecdd-42eb-818f-383280a8fca9"
]
- evidence_refs
[
{
"ref": "paper:987379eb-ecdd-42eb-818f-383280a8fca9"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}