Details

scope
rat, cortex, prefrontal cortex
claim_text
These findings raise the intriguing possibility that selective targeting of NRG1 activation of ErbB4 in PV+ or VIP+ interneurons could also potentially improve PFC plasticity in adults.
section_id
section_11
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json
review_repo
ComputationalReviewVIP
section_ref
wiki_page:computationalreviewvip-11-disease-translational
source_kind
review_finding
source_path
evidence/section_11_evidence_package.json
source_span
These findings raise the intriguing possibility that selective targeting of NRG1 activation of ErbB4 in PV+ or VIP+ interneurons could also potentially improve PFC plasticity in adults.
study_system
rat, cortex, prefrontal cortex
section_title
Species Differences, Human Relevance, and Disease
evidence_summary
Reported in study using rat, cortex, prefrontal cortex.
review_bundle_ref
analysis_bundle:ab-2ce40c33e827
replication_status
multiple_database_indexed
review_package_ref
analysis_bundle:ab-2ce40c33e827
source_artifact_ref
wiki_page:computationalreviewvip-11-disease-translational
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json
commit_sha
95e761177f7d2ec565983d3307c14ec238f9677c
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
raw_fields
{
  "n": 0,
  "doi": "10.1038/s41398-020-00868-5",
  "claim": "These findings raise the intriguing possibility that selective targeting of NRG1 activation of ErbB4 in PV+ or VIP+ interneurons could also potentially improve PFC plasticity in adults.",
  "title": null,
  "cite_key": "Shi2020",
  "evidence": "Reported in study using rat, cortex, prefrontal cortex.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "rat, cortex, prefrontal cortex",
  "_source_cluster": "cluster_10_species_disease",
  "replication_status": "multiple_database_indexed",
  "_source_cluster_index": 23,
  "claim_source_sentence": "These findings raise the intriguing possibility that selective targeting of NRG1 activation of ErbB4 in PV+ or VIP+ interneurons could also potentially improve PFC plasticity in adults.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:6e9f876b-8f89-4beb-8159-db17eb45aa4e"
]
evidence_refs
[
  {
    "ref": "paper:6e9f876b-8f89-4beb-8159-db17eb45aa4e"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

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