Mef2c is essential for PV interneuron development: conditional deletion results…

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scope: mouse MGE-derived interneurons, Lhx6-iCre Mef2c cKO
claim_text: Mef2c is essential for PV interneuron development: conditional deletion results in their loss after P6, and CUT&RUN reveals more loci specifically bound by MEF2C in PV than SST cells.
section_id: section_02_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
effect_size: loss of PV interneurons after P6 with Mef2c deletion; more MEF2C-specific loci in PV than SST
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-02
source_kind: review_finding
source_path: evidence/section_02_evidence_package.json
source_span: In a previous study, we found that Mef2c is essential for PV interneuron development, resulting in their loss after P6.
study_system: mouse MGE-derived interneurons, Lhx6-iCre Mef2c cKO
section_title: Molecular Identity and Transcriptomic Taxonomy
evidence_summary
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-02
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1038/s41586-021-03933-1",
  "claim": "Mef2c is essential for PV interneuron development: conditional deletion results in their loss after P6, and CUT&RUN reveals more loci specifically bound by MEF2C in PV than SST cells.",
  "evidence": "",
  "effect_size": "loss of PV interneurons after P6 with Mef2c deletion; more MEF2C-specific loci in PV than SST",
  "text_access": "fulltext",
  "study_system": "mouse MGE-derived interneurons, Lhx6-iCre Mef2c cKO",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "In a previous study, we found that Mef2c is essential for PV interneuron development, resulting in their loss after P6.",
  "replication_evidence_dois": [
    "10.1038/nature25999"
  ],
  "effect_size_source_sentence": "This work revealed both common and subtype-specific binding of MEF2C, with more loci specifically bound in PV cells compared to SST."
}

source_refs

[
  "paper:paper-1c4a74c94c96"
]

evidence_refs

[
  {
    "ref": "paper:paper-1c4a74c94c96"
  }
]

source_policy

{
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  "notes": [
    "Local review repositories are read-only inputs.",
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  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Mef2c is essential for PV interneuron development: conditional deletion results…

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