Version history

{
  "scope": "mouse MGE-derived interneurons, Lhx6-iCre Mef2c cKO",
  "claim_text": "Mef2c is essential for PV interneuron development: conditional deletion results in their loss after P6, and CUT&RUN reveals more loci specifically bound by MEF2C in PV than SST cells.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41586-021-03933-1",
    "claim": "Mef2c is essential for PV interneuron development: conditional deletion results in their loss after P6, and CUT&RUN reveals more loci specifically bound by MEF2C in PV than SST cells.",
    "evidence": "",
    "effect_size": "loss of PV interneurons after P6 with Mef2c deletion; more MEF2C-specific loci in PV than SST",
    "text_access": "fulltext",
    "study_system": "mouse MGE-derived interneurons, Lhx6-iCre Mef2c cKO",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "In a previous study, we found that Mef2c is essential for PV interneuron development, resulting in their loss after P6.",
    "replication_evidence_dois": [
      "10.1038/nature25999"
    ],
    "effect_size_source_sentence": "This work revealed both common and subtype-specific binding of MEF2C, with more loci specifically bound in PV cells compared to SST."
  },
  "section_id": "section_02_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json",
  "effect_size": "loss of PV interneurons after P6 with Mef2c deletion; more MEF2C-specific loci in PV than SST",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-02",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-1c4a74c94c96"
  ],
  "source_span": "In a previous study, we found that Mef2c is essential for PV interneuron development, resulting in their loss after P6.",
  "study_system": "mouse MGE-derived interneurons, Lhx6-iCre Mef2c cKO",
  "evidence_refs": [
    {
      "ref": "paper:paper-1c4a74c94c96"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-02",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}