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- Live5/17/2026, 4:35:28 PM
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{ "scope": "Awake mouse visual cortex; mesoscale two-photon calcium imaging", "claim_text": "Recording more than 10,000 neurons in awake mouse visual cortex shows that spontaneous activity reliably encodes a high-dimensional latent state related to ongoing behavior across the forebrain, and that sensory inputs add stimulus representations in orthogonal dimensions rather than interrupting the ongoing signal.", "raw_fields": { "n": 10000, "doi": "10.1126/science.aav7893", "claim": "Recording more than 10,000 neurons in awake mouse visual cortex shows that spontaneous activity reliably encodes a high-dimensional latent state related to ongoing behavior across the forebrain, and that sensory inputs add stimulus representations in orthogonal dimensions rather than interrupting the ongoing signal.", "cite_key": "Stringer2019b", "evidence": "Foundational large-scale 2P result motivating multidimensional analyses of mouse-cortex population codes; large-N enabled by mesoscope.", "effect_size": ">10,000 neurons simultaneously recorded in mouse visual cortex", "text_access": "abstract_only", "study_system": "Awake mouse visual cortex; mesoscale two-photon calcium imaging", "argument_role": "supporting", "replication_status": "single-study", "claim_source_sentence": "Recording more than 10,000 neurons in mouse visual cortex, we observed that spontaneous activity reliably encoded a high-dimensional latent state, which was partially related to the mouse's ongoing behavior and was represented not just in visual cortex but also across the forebrain.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": "Recording more than 10,000 neurons in mouse visual cortex, we observed that spontaneous activity reliably encoded a high-dimensional latent state, which was partially related to the mouse's ongoing behavior and was represented not just in visual cortex but also across the forebrain." }, "section_id": "section_16", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json", "effect_size": ">10,000 neurons simultaneously recorded in mouse visual cortex", "review_repo": "ComputationalReviewRecurrence", "section_ref": "wiki_page:computationalreviewrecurrence-16-synthesis", "source_kind": "review_finding", "source_path": "evidence/section_16_evidence_package.json", "source_refs": [ "paper:paper-d69a4ecd49f6" ], "source_span": "Recording more than 10,000 neurons in mouse visual cortex, we observed that spontaneous activity reliably encoded a high-dimensional latent state, which was partially related to the mouse's ongoing behavior and was represented not just in visual cortex but also across the forebrain.", "study_system": "Awake mouse visual cortex; mesoscale two-photon calcium imaging", "evidence_refs": [ { "ref": "paper:paper-d69a4ecd49f6" } ], "section_title": "16. Synthesis — which computational claims the mouse-cortex E→E empirical record actually supports, where the bottleneck observations are, and what an inhibition-free, single-species, basic-research analytic framing misses", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }, "evidence_summary": "Foundational large-scale 2P result motivating multidimensional analyses of mouse-cortex population codes; large-N enabled by mesoscope.", "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9", "replication_status": "single-study", "review_package_ref": "analysis_bundle:ab-d9c479db9be9", "source_artifact_ref": "wiki_page:computationalreviewrecurrence-16-synthesis", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json", "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }