Version history

{
  "scope": "mouse barrel L2 in vivo whole-cell",
  "claim_text": "In vivo two-photon-targeted paired recordings between mouse layer 2 barrel-cortex pyramidal neurons during the hyperpolarized down-state reveal a sparsely connected network (~6.7% connection probability) with overrepresentation of bidirectional pairs, small unitary EPSPs (<0.5 mV), and 22% failure rate, providing the first in vivo benchmark of L2/3 recurrent E→E translaminar connectivity.",
  "raw_fields": {
    "n": "in vivo two-photon multi-patch, n pairs in main text",
    "doi": "10.1016/j.celrep.2015.11.011",
    "claim": "In vivo two-photon-targeted paired recordings between mouse layer 2 barrel-cortex pyramidal neurons during the hyperpolarized down-state reveal a sparsely connected network (~6.7% connection probability) with overrepresentation of bidirectional pairs, small unitary EPSPs (<0.5 mV), and 22% failure rate, providing the first in vivo benchmark of L2/3 recurrent E→E translaminar connectivity.",
    "cite_key": "Jouhanneau2015",
    "evidence": "Two-photon-targeted multi-cell (2-4) whole-cell recordings of neighbouring L2 pyramidal cells in mouse barrel cortex in vivo.",
    "effect_size": "Connection probability 6.7%; failure rate 22%; CV = 0.74; mean PPR = 1.15; unitary EPSP <0.5 mV majority",
    "text_access": "fulltext",
    "study_system": "mouse barrel L2 in vivo whole-cell",
    "argument_role": "supporting",
    "replication_status": "consistent with sparse L2/3 recurrent connectivity (Lefort 2009; Avermann 2012)",
    "claim_source_sentence": "We made multiple (two to four) two-photon targeted whole-cell recordings from neighboring layer 2 mouse somatosensory barrel cortex pyramidal neurons in vivo... pyramidal neurons form a sparsely connected (6.7% connectivity) network with an overrepresentation of bidirectional connections. The majority of unitary excitatory postsynaptic potentials were small in amplitude (<0.5 mV), with a small minority >1 mV. The coefficient of variation (CV = 0.74) could largely be explained by the presence of synaptic failures (22%).",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2008.12.020"
    ],
    "effect_size_source_sentence": "pyramidal neurons form a sparsely connected (6.7% connectivity) network with an overrepresentation of bidirectional connections. ... CV = 0.74... synaptic failures (22%)."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Connection probability 6.7%; failure rate 22%; CV = 0.74; mean PPR = 1.15; unitary EPSP <0.5 mV majority",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-6d3d01cb91a6"
  ],
  "source_span": "We made multiple (two to four) two-photon targeted whole-cell recordings from neighboring layer 2 mouse somatosensory barrel cortex pyramidal neurons in vivo... pyramidal neurons form a sparsely connected (6.7% connectivity) network with an overrepresentation of bidirectional connections. The majority of unitary excitatory postsynaptic potentials were small in amplitude (<0.5 mV), with a small minority >1 mV. The co...",
  "study_system": "mouse barrel L2 in vivo whole-cell",
  "evidence_refs": [
    {
      "ref": "paper:paper-6d3d01cb91a6"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon-targeted multi-cell (2-4) whole-cell recordings of neighbouring L2 pyramidal cells in mouse barrel cortex in vivo.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "consistent with sparse L2/3 recurrent connectivity (Lefort 2009; Avermann 2012)",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}