Version history

{
  "scope": "adult mouse nervous system (CNS+PNS); ~500,000 single cells",
  "claim_text": "RNA sequencing of half a million single cells across the entire mouse nervous system produced a hierarchical, data-driven cell-type taxonomy in which neurons are grouped by developmental anatomical units and neurotransmitter/neuropeptide expression, with seven regionally restricted astrocyte types respecting developmental boundaries while oligodendrocytes show secondary regional diversification.",
  "raw_fields": {
    "n": 500000,
    "doi": "10.1016/j.cell.2018.06.021",
    "claim": "RNA sequencing of half a million single cells across the entire mouse nervous system produced a hierarchical, data-driven cell-type taxonomy in which neurons are grouped by developmental anatomical units and neurotransmitter/neuropeptide expression, with seven regionally restricted astrocyte types respecting developmental boundaries while oligodendrocytes show secondary regional diversification.",
    "cite_key": "Zeisel2018",
    "evidence": "Single-cell RNA sequencing of ~500,000 cells from the adult mouse nervous system, integrated across 19 dissected regions, produced a unified taxonomy of cell types and revealed regional restriction of astrocyte subtypes versus secondary diversification of oligodendrocytes.",
    "effect_size": "~500,000 single cells; 7 distinct astrocyte types",
    "text_access": "fulltext",
    "study_system": "adult mouse nervous system (CNS+PNS); ~500,000 single cells",
    "source_cluster_id": "cluster_14",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Here, we used RNA sequencing of half a million single cells to create a detailed census of cell types in the mouse nervous system.",
    "replication_evidence_dois": [
      "10.1038/s41586-021-03465-8",
      "10.1126/science.aar4237"
    ],
    "effect_size_source_sentence": "We discovered seven distinct, regionally restricted astrocyte types that obeyed developmental boundaries and correlated with the spatial distribution of key glutamate and glycine neurotransmitters."
  },
  "section_id": "section_15",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_15_evidence_package.json",
  "effect_size": "~500,000 single cells; 7 distinct astrocyte types",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-15",
  "source_kind": "review_finding",
  "source_path": "evidence/section_15_evidence_package.json",
  "source_refs": [
    "paper:paper-063a15662345"
  ],
  "source_span": "Here, we used RNA sequencing of half a million single cells to create a detailed census of cell types in the mouse nervous system.",
  "study_system": "adult mouse nervous system (CNS+PNS); ~500,000 single cells",
  "evidence_refs": [
    {
      "ref": "paper:paper-063a15662345"
    }
  ],
  "section_title": "Species Differences and Evolutionary Scaling of Loop Architecture",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Single-cell RNA sequencing of ~500,000 cells from the adult mouse nervous system, integrated across 19 dissected regions, produced a unified taxonomy of cell types and revealed regional restriction of astrocyte subtypes versus secondary diversification of oligodendrocytes.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-15",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_15_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}