Version history

{
  "scope": "mouse auditory cortex + mPFC; in vivo + in vitro optogenetics",
  "claim_text": "VIP-expressing interneurons make up roughly 10% of cortical inhibitory neurons and form a population distinct from the two major Pvalb and Sst groups; their disinhibitory role is exerted by transient suppression of primarily SST and a fraction of PV cells, and their activity is uniformly recruited by reinforcement signals (reward/punishment) across auditory and prefrontal cortex.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nature12676",
    "claim": "VIP-expressing interneurons make up roughly 10% of cortical inhibitory neurons and form a population distinct from the two major Pvalb and Sst groups; their disinhibitory role is exerted by transient suppression of primarily SST and a fraction of PV cells, and their activity is uniformly recruited by reinforcement signals (reward/punishment) across auditory and prefrontal cortex.",
    "title": null,
    "cite_key": "Pi2013",
    "evidence": "in vivo single-cell recordings + optogenetic activation in auditory and mPFC of awake mice (Pi et al 2013)",
    "effect_size": "VIP ≈ 10% of cortical INs; reinforcement signals 'strongly and uniformly' activate VIP",
    "text_access": "fulltext",
    "study_system": "mouse auditory cortex + mPFC; in vivo + in vitro optogenetics",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 53,
    "claim_source_sentence": "Indeed, VIP expression demarcates a small population of all interneurons (~10%), distinct from the two major interneuron populations defined by parvalbumin (Pv) and somatostatin (Som) expression.",
    "replication_evidence_dois": [
      "10.1038/nn.3446",
      "10.1016/j.neuron.2016.06.033"
    ],
    "effect_size_source_sentence": "we identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "VIP ≈ 10% of cortical INs; reinforcement signals 'strongly and uniformly' activate VIP",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-065a0eae69a5"
  ],
  "source_span": "Indeed, VIP expression demarcates a small population of all interneurons (~10%), distinct from the two major interneuron populations defined by parvalbumin (Pv) and somatostatin (Som) expression.",
  "study_system": "mouse auditory cortex + mPFC; in vivo + in vitro optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-065a0eae69a5"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "in vivo single-cell recordings + optogenetic activation in auditory and mPFC of awake mice (Pi et al 2013)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}