VIP-expressing interneurons make up roughly 10% of cortical inhibitory neurons…

VIP-expressing interneurons make up roughly 10% of cortical inhibitory neurons and form a population distinct from the two major Pvalb and Sst groups; their disinhibitory role is exerted by transient suppression of primarily SST and a fraction of PV cells, and their activity is uniformly recruited by reinforcement signals (reward/punishment) across auditory and prefrontal cortex.

{
  "n": null,
  "doi": "10.1038/nature12676",
  "claim": "VIP-expressing interneurons make up roughly 10% of cortical inhibitory neurons and form a population distinct from the two major Pvalb and Sst groups; their disinhibitory role is exerted by transient suppression of primarily SST and a fraction of PV cells, and their activity is uniformly recruited by reinforcement signals (reward/punishment) across auditory and prefrontal cortex.",
  "title": null,
  "cite_key": "Pi2013",
  "evidence": "in vivo single-cell recordings + optogenetic activation in auditory and mPFC of awake mice (Pi et al 2013)",
  "effect_size": "VIP ≈ 10% of cortical INs; reinforcement signals 'strongly and uniformly' activate VIP",
  "text_access": "fulltext",
  "study_system": "mouse auditory cortex + mPFC; in vivo + in vitro optogenetics",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 53,
  "claim_source_sentence": "Indeed, VIP expression demarcates a small population of all interneurons (~10%), distinct from the two major interneuron populations defined by parvalbumin (Pv) and somatostatin (Som) expression.",
  "replication_evidence_dois": [
    "10.1038/nn.3446",
    "10.1016/j.neuron.2016.06.033"
  ],
  "effect_size_source_sentence": "we identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons."
}

[
  "paper:paper-065a0eae69a5"
]

[
  {
    "ref": "paper:paper-065a0eae69a5"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}