- claim_text
In PV+ basket cell axons, complementary tuning of fast-inactivating Na+ channels and delayed Kv3-type K+ channels minimizes ion flux overlap during action potentials, achieving energy efficiency only ~1.6 times the theoretical minimum despite brief APs.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuron.2018.02.024",
"claim": "In PV+ basket cell axons, complementary tuning of fast-inactivating Na+ channels and delayed Kv3-type K+ channels minimizes ion flux overlap during action potentials, achieving energy efficiency only ~1.6 times the theoretical minimum despite brief APs.",
"evidence": "Direct recordings from PV+-BC axons showed the energy required for the AP was only ~1.6 times the theoretical minimum, achieved through complementary Na+ and K+ channel gating optimization.",
"effect_size": "~1.6x theoretical minimum energy per AP in PV+ basket cell axons",
"text_access": "fulltext",
"study_system": "PV+ basket cell axons, direct axonal recordings",
"replication_status": "replication_unknown",
"claim_source_sentence": "High energy efficiency emerged from the combination of fast inactivation of Na+ channels and delayed activation of Kv3-type K+ channels, which minimized ion flux overlap during APs.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "the energy required for the AP was, on average, only ~1.6 times the theoretical minimum."
}- source_refs
[
"paper:paper-e022e0b961a0"
]
- evidence_refs
[
{
"ref": "paper:paper-e022e0b961a0"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}