Version history

{
  "scope": "PV+ basket cell axons, direct axonal recordings",
  "claim_text": "In PV+ basket cell axons, complementary tuning of fast-inactivating Na+ channels and delayed Kv3-type K+ channels minimizes ion flux overlap during action potentials, achieving energy efficiency only ~1.6 times the theoretical minimum despite brief APs.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2018.02.024",
    "claim": "In PV+ basket cell axons, complementary tuning of fast-inactivating Na+ channels and delayed Kv3-type K+ channels minimizes ion flux overlap during action potentials, achieving energy efficiency only ~1.6 times the theoretical minimum despite brief APs.",
    "evidence": "Direct recordings from PV+-BC axons showed the energy required for the AP was only ~1.6 times the theoretical minimum, achieved through complementary Na+ and K+ channel gating optimization.",
    "effect_size": "~1.6x theoretical minimum energy per AP in PV+ basket cell axons",
    "text_access": "fulltext",
    "study_system": "PV+ basket cell axons, direct axonal recordings",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "High energy efficiency emerged from the combination of fast inactivation of Na+ channels and delayed activation of Kv3-type K+ channels, which minimized ion flux overlap during APs.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "the energy required for the AP was, on average, only ~1.6 times the theoretical minimum."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "~1.6x theoretical minimum energy per AP in PV+ basket cell axons",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-e022e0b961a0"
  ],
  "source_span": "High energy efficiency emerged from the combination of fast inactivation of Na+ channels and delayed activation of Kv3-type K+ channels, which minimized ion flux overlap during APs.",
  "study_system": "PV+ basket cell axons, direct axonal recordings",
  "evidence_refs": [
    {
      "ref": "paper:paper-e022e0b961a0"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Direct recordings from PV+-BC axons showed the energy required for the AP was only ~1.6 times the theoretical minimum, achieved through complementary Na+ and K+ channel gating optimization.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}