In mouse dmPFC during a goal-directed sensory discrimination task, VIP+ and PV+…

In mouse dmPFC during a goal-directed sensory discrimination task, VIP+ and PV+ interneurons preferentially signal punishment-related events (with VIP responding strongly to punishment) while SST+ neurons preferentially signal lick-bout/reward onset — providing distinct cell-type-specific task signals.

{
  "n": "VIP n=390, PV n=243, SST n=388, PYR n=631 task-modulated cells",
  "doi": "10.1016/j.neuron.2015.06.021",
  "claim": "In mouse dmPFC during a goal-directed sensory discrimination task, VIP+ and PV+ interneurons preferentially signal punishment-related events (with VIP responding strongly to punishment) while SST+ neurons preferentially signal lick-bout/reward onset — providing distinct cell-type-specific task signals.",
  "title": null,
  "cite_key": "Pinto2015",
  "evidence": "Cellular-resolution microendoscopic Ca2+ imaging in mouse dmPFC during a sensory discrimination task with rewards and punishments.",
  "effect_size": "Task-modulated fraction: PV 95.3%, SST 96.9%, VIP 81.2%, PYR 77.3%; CC for VIP=0.31±0.01 (n=390), PYR=0.24±0.01 (n=631).",
  "text_access": "fulltext",
  "study_system": "mouse dmPFC; in vivo microendoscopic GCaMP6f imaging",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "single-study",
  "_source_cluster_index": 34,
  "claim_source_sentence": "Significant PN responses were found in VIP + , PV + , and PYR neurons ( ; p < 10 −10 , signed rank test), but not in SST + neurons (p = 0.61), while RW responses were larger in PV + neurons than all other cell types.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "However, the percentage of neurons that were significantly modulated by the task (p < 0.01, 3-way ANOVA, see Experimental Procedures) differed across cell types, higher for PV + (95.3%) and SST + (96.9%) than for VIP + (81.2%) and PYR (77.3%) neurons."
}

[
  "paper:paper-6fb6c7efe883"
]

[
  {
    "ref": "paper:paper-6fb6c7efe883"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}