Version history

{
  "scope": "mouse whole cortex; layer- and class-specific (L2/3, L4, L5 IT/PT, L6 CT) Cre-line viral tracing co-registered with rs-fMRI DMN",
  "claim_text": "Layer- and class-specific cortico-cortical projection mapping across 14 mouse Cre lines shows that the mouse default-mode network (DMN) is supported by intratelencephalic (IT) pyramidal projections from L2/3 and L5: L5 IT cells generally project to a larger set of cortical targets than L2/3 IT cells, defining a class-specific cortico-cortical scaffold of long-range mouse intracortical excitation.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2020.11.011",
    "claim": "Layer- and class-specific cortico-cortical projection mapping across 14 mouse Cre lines shows that the mouse default-mode network (DMN) is supported by intratelencephalic (IT) pyramidal projections from L2/3 and L5: L5 IT cells generally project to a larger set of cortical targets than L2/3 IT cells, defining a class-specific cortico-cortical scaffold of long-range mouse intracortical excitation.",
    "cite_key": "Whitesell2021",
    "evidence": "Co-registration of Allen Mouse Brain Connectivity Atlas viral tracing (14 layer- and class-specific Cre lines: L2/3, L4, L5 IT, L5 PT, L6 CT) with resting-state-fMRI–derived DMN maps in mouse; quantification of class-specific intracortical projection patterns onto DMN hub regions.",
    "effect_size": "L5 IT cells project to more cortical targets than L2/3 IT cells",
    "text_access": "fulltext",
    "study_system": "mouse whole cortex; layer- and class-specific (L2/3, L4, L5 IT/PT, L6 CT) Cre-line viral tracing co-registered with rs-fMRI DMN",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Although many corticocortical projections originate from L2/3 and L5, the L5 IT class generally projects to a larger set of targets.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1093/cercor/bhac052",
      "10.34133/research.0470"
    ],
    "effect_size_source_sentence": "Although many corticocortical projections originate from L2/3 and L5, the L5 IT class generally projects to a larger set of targets."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "L5 IT cells project to more cortical targets than L2/3 IT cells",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-68f488c15f96"
  ],
  "source_span": "Although many corticocortical projections originate from L2/3 and L5, the L5 IT class generally projects to a larger set of targets.",
  "study_system": "mouse whole cortex; layer- and class-specific (L2/3, L4, L5 IT/PT, L6 CT) Cre-line viral tracing co-registered with rs-fMRI DMN",
  "evidence_refs": [
    {
      "ref": "paper:paper-68f488c15f96"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Co-registration of Allen Mouse Brain Connectivity Atlas viral tracing (14 layer- and class-specific Cre lines: L2/3, L4, L5 IT, L5 PT, L6 CT) with resting-state-fMRI–derived DMN maps in mouse; quantification of class-specific intracortical projection patterns onto DMN hub regions.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}