Layer- and class-specific cortico-cortical projection mapping across 14 mouse C…

Layer- and class-specific cortico-cortical projection mapping across 14 mouse Cre lines shows that the mouse default-mode network (DMN) is supported by intratelencephalic (IT) pyramidal projections from L2/3 and L5: L5 IT cells generally project to a larger set of cortical targets than L2/3 IT cells, defining a class-specific cortico-cortical scaffold of long-range mouse intracortical excitation.

{
  "n": 0,
  "doi": "10.1016/j.neuron.2020.11.011",
  "claim": "Layer- and class-specific cortico-cortical projection mapping across 14 mouse Cre lines shows that the mouse default-mode network (DMN) is supported by intratelencephalic (IT) pyramidal projections from L2/3 and L5: L5 IT cells generally project to a larger set of cortical targets than L2/3 IT cells, defining a class-specific cortico-cortical scaffold of long-range mouse intracortical excitation.",
  "cite_key": "Whitesell2021",
  "evidence": "Co-registration of Allen Mouse Brain Connectivity Atlas viral tracing (14 layer- and class-specific Cre lines: L2/3, L4, L5 IT, L5 PT, L6 CT) with resting-state-fMRI–derived DMN maps in mouse; quantification of class-specific intracortical projection patterns onto DMN hub regions.",
  "effect_size": "L5 IT cells project to more cortical targets than L2/3 IT cells",
  "text_access": "fulltext",
  "study_system": "mouse whole cortex; layer- and class-specific (L2/3, L4, L5 IT/PT, L6 CT) Cre-line viral tracing co-registered with rs-fMRI DMN",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Although many corticocortical projections originate from L2/3 and L5, the L5 IT class generally projects to a larger set of targets.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1093/cercor/bhac052",
    "10.34133/research.0470"
  ],
  "effect_size_source_sentence": "Although many corticocortical projections originate from L2/3 and L5, the L5 IT class generally projects to a larger set of targets."
}

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Co-registration of Allen Mouse Brain Connectivity Atlas viral tracing (14 layer- and class-specific Cre lines: L2/3, L4, L5 IT, L5 PT, L6 CT) with resting-state-fMRI–derived DMN maps in mouse; quantification of class-specific intracortical projection patterns onto DMN hub regions.