Version history

{
  "scope": "mouse (postnatal striatum scRNA-seq + cKO)",
  "claim_text": "Single-cell RNA sequencing of the early postnatal mouse striatum shows that the autism/ID risk gene Foxp1 regulates cellular composition, neurochemical architecture and connectivity in a cell-type-dependent fashion across striatal cell types.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.celrep.2020.02.030",
    "claim": "Single-cell RNA sequencing of the early postnatal mouse striatum shows that the autism/ID risk gene Foxp1 regulates cellular composition, neurochemical architecture and connectivity in a cell-type-dependent fashion across striatal cell types.",
    "cite_key": "Anderson2020",
    "evidence": "scRNA-seq of postnatal striatum from Foxp1 conditional knockout vs control; behavioral/functional follow-up.",
    "effect_size": "qualitative — cell-type-dependent Foxp1-regulated transcriptional programs",
    "text_access": "abstract_only",
    "study_system": "mouse (postnatal striatum scRNA-seq + cKO)",
    "source_cluster_id": "cluster_03",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Using single-cell RNA sequencing (RNA-seq), we examine the cellular diversity of the early postnatal striatum and show that Foxp1, a transcription factor strongly linked to autism and intellectual disability, regulates the cellular composition, neurochemical architecture, and connectivity of the striatum in a cell-type-dependent fashion.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Using this approach, we could also examine the non-cell-autonomous effects produced by disrupting one cell type and the molecular compensation that occurs in other populations."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "effect_size": "qualitative — cell-type-dependent Foxp1-regulated transcriptional programs",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:2fb0d69a-a5e5-4629-9856-1d98636e335e"
  ],
  "source_span": "Using single-cell RNA sequencing (RNA-seq), we examine the cellular diversity of the early postnatal striatum and show that Foxp1, a transcription factor strongly linked to autism and intellectual disability, regulates the cellular composition, neurochemical architecture, and connectivity of the striatum in a cell-type-dependent fashion.",
  "study_system": "mouse (postnatal striatum scRNA-seq + cKO)",
  "evidence_refs": [
    {
      "ref": "paper:2fb0d69a-a5e5-4629-9856-1d98636e335e"
    }
  ],
  "section_title": "The Cortico-Striatal Interface: Topography, Cell Types, and Input Convergence",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "scRNA-seq of postnatal striatum from Foxp1 conditional knockout vs control; behavioral/functional follow-up.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}