Single-cell RNA sequencing of the early postnatal mouse striatum shows that the…

Single-cell RNA sequencing of the early postnatal mouse striatum shows that the autism/ID risk gene Foxp1 regulates cellular composition, neurochemical architecture and connectivity in a cell-type-dependent fashion across striatal cell types.

{
  "n": null,
  "doi": "10.1016/j.celrep.2020.02.030",
  "claim": "Single-cell RNA sequencing of the early postnatal mouse striatum shows that the autism/ID risk gene Foxp1 regulates cellular composition, neurochemical architecture and connectivity in a cell-type-dependent fashion across striatal cell types.",
  "cite_key": "Anderson2020",
  "evidence": "scRNA-seq of postnatal striatum from Foxp1 conditional knockout vs control; behavioral/functional follow-up.",
  "effect_size": "qualitative — cell-type-dependent Foxp1-regulated transcriptional programs",
  "text_access": "abstract_only",
  "study_system": "mouse (postnatal striatum scRNA-seq + cKO)",
  "source_cluster_id": "cluster_03",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Using single-cell RNA sequencing (RNA-seq), we examine the cellular diversity of the early postnatal striatum and show that Foxp1, a transcription factor strongly linked to autism and intellectual disability, regulates the cellular composition, neurochemical architecture, and connectivity of the striatum in a cell-type-dependent fashion.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Using this approach, we could also examine the non-cell-autonomous effects produced by disrupting one cell type and the molecular compensation that occurs in other populations."
}

[
  "paper:2fb0d69a-a5e5-4629-9856-1d98636e335e"
]

Using single-cell RNA sequencing (RNA-seq), we examine the cellular diversity of the early postnatal striatum and show that Foxp1, a transcription factor strongly linked to autism and intellectual disability, regulates the cellular composition, neurochemical architecture, and connectivity of the striatum in a cell-type-dependent fashion.

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