Version history

{
  "scope": "vip-interneurons",
  "claim_text": "During the binocular critical period of mouse V1, basal-forebrain acetylcholine released during arousal directly excites SST interneurons (not VIP) to produce localized dendritic spiking and disinhibition needed for binocular plasticity; this cholinergic sensitivity is lost in adulthood.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41586-019-0963-3",
    "year": "2019",
    "claim": "During the binocular critical period of mouse V1, basal-forebrain acetylcholine released during arousal directly excites SST interneurons (not VIP) to produce localized dendritic spiking and disinhibition needed for binocular plasticity; this cholinergic sensitivity is lost in adulthood.",
    "title": "Neuromodulatory control of localized dendritic spiking in critical period cortex",
    "journal": "",
    "species": "mouse",
    "cite_key": "Yaeger2019",
    "evidence": "In vivo two-photon Ca2+ imaging + slice electrophysiology + optogenetics in critical-period vs. adult mouse V1.",
    "effect_size": "In adults SST cells lost cholinergic sensitivity; binocular receptive fields failed to develop when SST cells were silenced.",
    "text_access": "fulltext",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "single_study",
    "_source_cluster_index": 20,
    "claim_source_sentence": "At the peak of the critical period for binocular plasticity, acetylcholine released from the basal forebrain during periods of heightened arousal directly excites somatostatin-expressing (SST) interneurons.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "By adulthood, this cholinergic sensitivity is lost, and compartmentalized dendritic responses are absent but can be re-instated by optogenetic activation of SST cells."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "effect_size": "In adults SST cells lost cholinergic sensitivity; binocular receptive fields failed to develop when SST cells were silenced.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-d2aa74034d77"
  ],
  "source_span": "At the peak of the critical period for binocular plasticity, acetylcholine released from the basal forebrain during periods of heightened arousal directly excites somatostatin-expressing (SST) interneurons.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-d2aa74034d77"
    }
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "In vivo two-photon Ca2+ imaging + slice electrophysiology + optogenetics in critical-period vs. adult mouse V1.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}