During the binocular critical period of mouse V1, basal-forebrain acetylcholine…

During the binocular critical period of mouse V1, basal-forebrain acetylcholine released during arousal directly excites SST interneurons (not VIP) to produce localized dendritic spiking and disinhibition needed for binocular plasticity; this cholinergic sensitivity is lost in adulthood.

{
  "n": null,
  "doi": "10.1038/s41586-019-0963-3",
  "year": "2019",
  "claim": "During the binocular critical period of mouse V1, basal-forebrain acetylcholine released during arousal directly excites SST interneurons (not VIP) to produce localized dendritic spiking and disinhibition needed for binocular plasticity; this cholinergic sensitivity is lost in adulthood.",
  "title": "Neuromodulatory control of localized dendritic spiking in critical period cortex",
  "journal": "",
  "species": "mouse",
  "cite_key": "Yaeger2019",
  "evidence": "In vivo two-photon Ca2+ imaging + slice electrophysiology + optogenetics in critical-period vs. adult mouse V1.",
  "effect_size": "In adults SST cells lost cholinergic sensitivity; binocular receptive fields failed to develop when SST cells were silenced.",
  "text_access": "fulltext",
  "_source_cluster": "cluster_13_neuromodulation",
  "replication_status": "single_study",
  "_source_cluster_index": 20,
  "claim_source_sentence": "At the peak of the critical period for binocular plasticity, acetylcholine released from the basal forebrain during periods of heightened arousal directly excites somatostatin-expressing (SST) interneurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "By adulthood, this cholinergic sensitivity is lost, and compartmentalized dendritic responses are absent but can be re-instated by optogenetic activation of SST cells."
}

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  "paper:paper-d2aa74034d77"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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