- claim_text
In mouse motor cortex, layer-6 corticothalamic neurons make strong reciprocal connections with other CT and IT neurons but strikingly little excitatory connectivity to PT pyramidal-tract neurons, and M1-CT and ventrolateral thalamocortical neurons are remarkably unconnected in either direction — contrasting with sensory cortex.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.4023-14.2015",
"claim": "In mouse motor cortex, layer-6 corticothalamic neurons make strong reciprocal connections with other CT and IT neurons but strikingly little excitatory connectivity to PT pyramidal-tract neurons, and M1-CT and ventrolateral thalamocortical neurons are remarkably unconnected in either direction — contrasting with sensory cortex.",
"cite_key": "Yamawaki2015",
"evidence": "Multi-method circuit analysis (laser scanning photostimulation + paired patch + optogenetics) in mouse forelimb M1.",
"effect_size": "",
"text_access": "abstract_only",
"study_system": "mouse forelimb M1 in vitro",
"source_cluster_id": "cluster_01",
"replication_status": "replication_unknown",
"claim_source_sentence": "Stimulating and recording from CT, intratelencephalic (IT), and pyramidal tract (PT) projection neurons, we found strong CT↔ CT and CT↔ IT connections; however, CT→IT connections were limited to IT neurons in layer 6, not 5B. There was strikingly little CT↔ PT excitatory connectivity. ... we found that M1-CT neurons and thalamocortical neurons in the ventrolateral (VL) nucleus were remarkably unconnected in either direction.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-77ff3f69a352"
]
- source_span
Stimulating and recording from CT, intratelencephalic (IT), and pyramidal tract (PT) projection neurons, we found strong CT↔ CT and CT↔ IT connections; however, CT→IT connections were limited to IT neurons in layer 6, not 5B. There was strikingly little CT↔ PT excitatory connectivity. ... we found that M1-CT neurons and thalamocortical neurons in the ventrolateral (VL) nucleus were remarkably unconnected in either d...
- evidence_refs
[
{
"ref": "paper:paper-77ff3f69a352"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}