Version history

{
  "scope": "Mouse V1 L2/3, awake; two-photon single-cell holographic optogenetics + calcium imaging",
  "claim_text": "Targeted two-photon optogenetic stimulation of single excitatory neurons in mouse V1 L2/3 produces, on average, suppression of nearby neurons with a center-surround profile and feature-specific (like-suppresses-like) competition, providing direct in vivo measurements of recurrent network influence consistent with strongly coupled E-I circuits.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41586-019-0997-6",
    "claim": "Targeted two-photon optogenetic stimulation of single excitatory neurons in mouse V1 L2/3 produces, on average, suppression of nearby neurons with a center-surround profile and feature-specific (like-suppresses-like) competition, providing direct in vivo measurements of recurrent network influence consistent with strongly coupled E-I circuits.",
    "cite_key": "Chettih2019",
    "evidence": "Single-cell two-photon optogenetic stimulation (influence mapping) combined with calcium imaging in mouse V1 L2/3 in awake animals viewing visual stimuli.",
    "effect_size": "~2% decrease in population response to targeted neuron's preferred stimulus; like-suppresses-like motif statistically significant",
    "text_access": "fulltext",
    "study_system": "Mouse V1 L2/3, awake; two-photon single-cell holographic optogenetics + calcium imaging",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Excitatory neurons on average suppressed other neurons and had a centre-surround influence profile over anatomical space.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2023.09.010",
      "10.7554/eLife.58889"
    ],
    "effect_size_source_sentence": "In addition, photostimulation reduced the population response, specifically to the targeted neuron's preferred stimulus, by around 2%."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "~2% decrease in population response to targeted neuron's preferred stimulus; like-suppresses-like motif statistically significant",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-31f54bcea8a4"
  ],
  "source_span": "Excitatory neurons on average suppressed other neurons and had a centre-surround influence profile over anatomical space.",
  "study_system": "Mouse V1 L2/3, awake; two-photon single-cell holographic optogenetics + calcium imaging",
  "evidence_refs": [
    {
      "ref": "paper:paper-31f54bcea8a4"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Single-cell two-photon optogenetic stimulation (influence mapping) combined with calcium imaging in mouse V1 L2/3 in awake animals viewing visual stimuli.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}