Details
- scope
- Mouse V1 L2/3, awake; two-photon single-cell holographic optogenetics + calcium imaging
- section_id
- section_09
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
- effect_size
- ~2% decrease in population response to targeted neuron's preferred stimulus; like-suppresses-like motif statistically significant
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-09-amplification-isn
- source_kind
- review_finding
- source_path
- evidence/section_09_evidence_package.json
- source_span
- Excitatory neurons on average suppressed other neurons and had a centre-surround influence profile over anatomical space.
- study_system
- Mouse V1 L2/3, awake; two-photon single-cell holographic optogenetics + calcium imaging
- section_title
- 9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation
- evidence_summary
- Single-cell two-photon optogenetic stimulation (influence mapping) combined with calcium imaging in mouse V1 L2/3 in awake animals viewing visual stimuli.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-09-amplification-isn
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- claim_text
Targeted two-photon optogenetic stimulation of single excitatory neurons in mouse V1 L2/3 produces, on average, suppression of nearby neurons with a center-surround profile and feature-specific (like-suppresses-like) competition, providing direct in vivo measurements of recurrent network influence consistent with strongly coupled E-I circuits.
- raw_fields
{ "n": 0, "doi": "10.1038/s41586-019-0997-6", "claim": "Targeted two-photon optogenetic stimulation of single excitatory neurons in mouse V1 L2/3 produces, on average, suppression of nearby neurons with a center-surround profile and feature-specific (like-suppresses-like) competition, providing direct in vivo measurements of recurrent network influence consistent with strongly coupled E-I circuits.", "cite_key": "Chettih2019", "evidence": "Single-cell two-photon optogenetic stimulation (influence mapping) combined with calcium imaging in mouse V1 L2/3 in awake animals viewing visual stimuli.", "effect_size": "~2% decrease in population response to targeted neuron's preferred stimulus; like-suppresses-like motif statistically significant", "text_access": "fulltext", "study_system": "Mouse V1 L2/3, awake; two-photon single-cell holographic optogenetics + calcium imaging", "argument_role": "supporting", "replication_status": "independently_replicated", "claim_source_sentence": "Excitatory neurons on average suppressed other neurons and had a centre-surround influence profile over anatomical space.", "source_provenance_status": "ok", "replication_evidence_dois": [ "10.1016/j.neuron.2023.09.010", "10.7554/eLife.58889" ], "effect_size_source_sentence": "In addition, photostimulation reduced the population response, specifically to the targeted neuron's preferred stimulus, by around 2%." }- source_refs
[ "paper:paper-31f54bcea8a4" ]
- evidence_refs
[ { "ref": "paper:paper-31f54bcea8a4" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }