Version history

{
  "scope": "mouse neocortex, Kv3.2 knockout",
  "claim_text": "Kv3.2 knockout mice show impaired high-frequency firing specifically in deep cortical layer (5-6) fast-spiking interneurons where Kv3.2 is normally prominent, but not in superficial layer FS neurons where Kv3.2 is weakly expressed, with increased seizure susceptibility from suppressed cortical inhibition.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.20-24-09071.2000",
    "claim": "Kv3.2 knockout mice show impaired high-frequency firing specifically in deep cortical layer (5-6) fast-spiking interneurons where Kv3.2 is normally prominent, but not in superficial layer FS neurons where Kv3.2 is weakly expressed, with increased seizure susceptibility from suppressed cortical inhibition.",
    "evidence": "Gene-targeted Kv3.2 knockout mice showed layer-specific FS impairment, altered cortical EEG, and increased epileptic seizure susceptibility consistent with impaired cortical inhibition.",
    "effect_size": "impaired FS firing in deep layers; altered EEG patterns; increased seizure susceptibility",
    "text_access": "abstract_only",
    "study_system": "mouse neocortex, Kv3.2 knockout",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "The ability to fire spikes at high frequencies was impaired in immunocytochemically identified FS interneurons of deep cortical layers (5-6) in which Kv3.2 proteins are normally prominent. No such impairment was found for FS neurons of superficial layers (2-4).",
    "replication_evidence_dois": [
      "10.1523/jneurosci.0722-05.2005"
    ],
    "effect_size_source_sentence": "Kv3.2 -/- mice showed specific alterations in their cortical EEG patterns and an increased susceptibility to epileptic seizures consistent with an impairment of cortical inhibitory mechanisms."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "impaired FS firing in deep layers; altered EEG patterns; increased seizure susceptibility",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-08e60421a6c7"
  ],
  "source_span": "The ability to fire spikes at high frequencies was impaired in immunocytochemically identified FS interneurons of deep cortical layers (5-6) in which Kv3.2 proteins are normally prominent. No such impairment was found for FS neurons of superficial layers (2-4).",
  "study_system": "mouse neocortex, Kv3.2 knockout",
  "evidence_refs": [
    {
      "ref": "paper:paper-08e60421a6c7"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Gene-targeted Kv3.2 knockout mice showed layer-specific FS impairment, altered cortical EEG, and increased epileptic seizure susceptibility consistent with impaired cortical inhibition.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}