- claim_text
Kv3.2 knockout mice show impaired high-frequency firing specifically in deep cortical layer (5-6) fast-spiking interneurons where Kv3.2 is normally prominent, but not in superficial layer FS neurons where Kv3.2 is weakly expressed, with increased seizure susceptibility from suppressed cortical inhibition.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.20-24-09071.2000",
"claim": "Kv3.2 knockout mice show impaired high-frequency firing specifically in deep cortical layer (5-6) fast-spiking interneurons where Kv3.2 is normally prominent, but not in superficial layer FS neurons where Kv3.2 is weakly expressed, with increased seizure susceptibility from suppressed cortical inhibition.",
"evidence": "Gene-targeted Kv3.2 knockout mice showed layer-specific FS impairment, altered cortical EEG, and increased epileptic seizure susceptibility consistent with impaired cortical inhibition.",
"effect_size": "impaired FS firing in deep layers; altered EEG patterns; increased seizure susceptibility",
"text_access": "abstract_only",
"study_system": "mouse neocortex, Kv3.2 knockout",
"replication_status": "independently_replicated",
"claim_source_sentence": "The ability to fire spikes at high frequencies was impaired in immunocytochemically identified FS interneurons of deep cortical layers (5-6) in which Kv3.2 proteins are normally prominent. No such impairment was found for FS neurons of superficial layers (2-4).",
"replication_evidence_dois": [
"10.1523/jneurosci.0722-05.2005"
],
"effect_size_source_sentence": "Kv3.2 -/- mice showed specific alterations in their cortical EEG patterns and an increased susceptibility to epileptic seizures consistent with an impairment of cortical inhibitory mechanisms."
}- source_refs
[
"paper:paper-08e60421a6c7"
]
- source_span
The ability to fire spikes at high frequencies was impaired in immunocytochemically identified FS interneurons of deep cortical layers (5-6) in which Kv3.2 proteins are normally prominent. No such impairment was found for FS neurons of superficial layers (2-4).
- evidence_refs
[
{
"ref": "paper:paper-08e60421a6c7"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}