Version history

{
  "scope": "Mouse forelimb M1 and M2; multiplexed MAPseq of PT axons.",
  "claim_text": "MAPseq analysis of pyramidal-tract projections from mouse forelimb M1 and M2 shows that the four basic axon subclasses (M1-CSPI, M1-CBULB, M2-CSPI, M2-CBULB) have both shared and distinct brainstem-collateral patterns, indicating that PT neurons in adjacent forelimb motor areas carry projection sub-structure beyond the M1/M2 dichotomy.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.1062-22.2022",
    "claim": "MAPseq analysis of pyramidal-tract projections from mouse forelimb M1 and M2 shows that the four basic axon subclasses (M1-CSPI, M1-CBULB, M2-CSPI, M2-CBULB) have both shared and distinct brainstem-collateral patterns, indicating that PT neurons in adjacent forelimb motor areas carry projection sub-structure beyond the M1/M2 dichotomy.",
    "cite_key": "Hausmann2022",
    "evidence": "Multiplexed MAPseq barcoded mapping of PT axons from forelimb M1 and M2 in mice of both sexes; brainstem collateral patterns quantified.",
    "effect_size": "Four PT subclass categories distinguished by area-of-origin and spinal-vs-bulbar target; shared and distinct collateral patterns.",
    "text_access": "abstract_only",
    "study_system": "Mouse forelimb M1 and M2; multiplexed MAPseq of PT axons.",
    "argument_role": "supporting",
    "replication_status": "replicated",
    "claim_source_sentence": "The four basic axon subclasses comprising these projections (M1-CSPI, M1-CBULB, M2-CSPI, M2-CBULB) showed a complex mix of differences and similarities.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1038/s41586-021-03970-w"
    ],
    "effect_size_source_sentence": "In experiments using mice of both sexes, we first confirmed prior results demonstrating the basic efficacy of axonal barcode identification of primary motor cortex (M1) PT-type axons, including corticobulbar (CBULB) and corticospinal (CSPI) subclasses."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "Four PT subclass categories distinguished by area-of-origin and spinal-vs-bulbar target; shared and distinct collateral patterns.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-9c44f8966e47"
  ],
  "source_span": "The four basic axon subclasses comprising these projections (M1-CSPI, M1-CBULB, M2-CSPI, M2-CBULB) showed a complex mix of differences and similarities.",
  "study_system": "Mouse forelimb M1 and M2; multiplexed MAPseq of PT axons.",
  "evidence_refs": [
    {
      "ref": "paper:paper-9c44f8966e47"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Multiplexed MAPseq barcoded mapping of PT axons from forelimb M1 and M2 in mice of both sexes; brainstem collateral patterns quantified.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}