MAPseq analysis of pyramidal-tract projections from mouse forelimb M1 and M2 sh…

MAPseq analysis of pyramidal-tract projections from mouse forelimb M1 and M2 shows that the four basic axon subclasses (M1-CSPI, M1-CBULB, M2-CSPI, M2-CBULB) have both shared and distinct brainstem-collateral patterns, indicating that PT neurons in adjacent forelimb motor areas carry projection sub-structure beyond the M1/M2 dichotomy.

{
  "n": null,
  "doi": "10.1523/jneurosci.1062-22.2022",
  "claim": "MAPseq analysis of pyramidal-tract projections from mouse forelimb M1 and M2 shows that the four basic axon subclasses (M1-CSPI, M1-CBULB, M2-CSPI, M2-CBULB) have both shared and distinct brainstem-collateral patterns, indicating that PT neurons in adjacent forelimb motor areas carry projection sub-structure beyond the M1/M2 dichotomy.",
  "cite_key": "Hausmann2022",
  "evidence": "Multiplexed MAPseq barcoded mapping of PT axons from forelimb M1 and M2 in mice of both sexes; brainstem collateral patterns quantified.",
  "effect_size": "Four PT subclass categories distinguished by area-of-origin and spinal-vs-bulbar target; shared and distinct collateral patterns.",
  "text_access": "abstract_only",
  "study_system": "Mouse forelimb M1 and M2; multiplexed MAPseq of PT axons.",
  "argument_role": "supporting",
  "replication_status": "replicated",
  "claim_source_sentence": "The four basic axon subclasses comprising these projections (M1-CSPI, M1-CBULB, M2-CSPI, M2-CBULB) showed a complex mix of differences and similarities.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/s41586-021-03970-w"
  ],
  "effect_size_source_sentence": "In experiments using mice of both sexes, we first confirmed prior results demonstrating the basic efficacy of axonal barcode identification of primary motor cortex (M1) PT-type axons, including corticobulbar (CBULB) and corticospinal (CSPI) subclasses."
}

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