Version history

{
  "scope": "mouse S1 L2/3 callosal/association pyramidal neurons, sparse anatomical tracing, postnatal",
  "claim_text": "In mouse cortex, most long-range S1→M1 association axons from layer 2/3 pyramidal neurons arise postnatally as interstitial collaterals branching from existing callosal axons of the same neurons, so a single L2/3 pyramidal cell carries both intracortical (association) and intercortical (callosal) projections.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1093/cercor/bhab153",
    "claim": "In mouse cortex, most long-range S1→M1 association axons from layer 2/3 pyramidal neurons arise postnatally as interstitial collaterals branching from existing callosal axons of the same neurons, so a single L2/3 pyramidal cell carries both intracortical (association) and intercortical (callosal) projections.",
    "cite_key": "Oka2021",
    "evidence": "Sparse single-neuron labeling in mouse S1 L2/3 by in utero electroporation with a Cre-driver under a gene promoter expressed broadly in callosal-association L2/3 neurons; serial confocal reconstruction of axon trajectories from S1 across postnatal development.",
    "effect_size": "Majority of long S1→M1 association axons identified as interstitial side-branches of callosal axons",
    "text_access": "fulltext",
    "study_system": "mouse S1 L2/3 callosal/association pyramidal neurons, sparse anatomical tracing, postnatal",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "Using single-neuron tracing, we demonstrated that most long association projections from layer 2/3 neurons in S1 to M1 arose as interstitial collaterals that extended postnatally from existing callosal axons.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Since our results demonstrate that a single neuron possesses both intracortical (association) and intercortical (callosal) projections, we propose that association projections formed as interstitial collaterals from dual-projection neurons constitute a conserved mechanism among the mammalian species."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "Majority of long S1→M1 association axons identified as interstitial side-branches of callosal axons",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-ed60bfe85054"
  ],
  "source_span": "Using single-neuron tracing, we demonstrated that most long association projections from layer 2/3 neurons in S1 to M1 arose as interstitial collaterals that extended postnatally from existing callosal axons.",
  "study_system": "mouse S1 L2/3 callosal/association pyramidal neurons, sparse anatomical tracing, postnatal",
  "evidence_refs": [
    {
      "ref": "paper:paper-ed60bfe85054"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Sparse single-neuron labeling in mouse S1 L2/3 by in utero electroporation with a Cre-driver under a gene promoter expressed broadly in callosal-association L2/3 neurons; serial confocal reconstruction of axon trajectories from S1 across postnatal development.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}