In mouse cortex, most long-range S1→M1 association axons from layer 2/3 pyramid…

In mouse cortex, most long-range S1→M1 association axons from layer 2/3 pyramidal neurons arise postnatally as interstitial collaterals branching from existing callosal axons of the same neurons, so a single L2/3 pyramidal cell carries both intracortical (association) and intercortical (callosal) projections.

{
  "n": 0,
  "doi": "10.1093/cercor/bhab153",
  "claim": "In mouse cortex, most long-range S1→M1 association axons from layer 2/3 pyramidal neurons arise postnatally as interstitial collaterals branching from existing callosal axons of the same neurons, so a single L2/3 pyramidal cell carries both intracortical (association) and intercortical (callosal) projections.",
  "cite_key": "Oka2021",
  "evidence": "Sparse single-neuron labeling in mouse S1 L2/3 by in utero electroporation with a Cre-driver under a gene promoter expressed broadly in callosal-association L2/3 neurons; serial confocal reconstruction of axon trajectories from S1 across postnatal development.",
  "effect_size": "Majority of long S1→M1 association axons identified as interstitial side-branches of callosal axons",
  "text_access": "fulltext",
  "study_system": "mouse S1 L2/3 callosal/association pyramidal neurons, sparse anatomical tracing, postnatal",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Using single-neuron tracing, we demonstrated that most long association projections from layer 2/3 neurons in S1 to M1 arose as interstitial collaterals that extended postnatally from existing callosal axons.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Since our results demonstrate that a single neuron possesses both intracortical (association) and intercortical (callosal) projections, we propose that association projections formed as interstitial collaterals from dual-projection neurons constitute a conserved mechanism among the mammalian species."
}

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Sparse single-neuron labeling in mouse S1 L2/3 by in utero electroporation with a Cre-driver under a gene promoter expressed broadly in callosal-association L2/3 neurons; serial confocal reconstruction of axon trajectories from S1 across postnatal development.