Version history

{
  "scope": "mouse barrel cortex, developmental slice paired recordings",
  "claim_text": "In developing mouse barrel cortex before the critical period, layer 2/3 horizontal connections between adjacent columns exhibit all-LTP STDP (pre-post and post-pre pairings both produce LTP), requiring NMDAR activation and PKA signalling, consistent with circuit-formation rules at L4→L2/3 and thalamocortical synapses during early development.",
  "raw_fields": {
    "n": "developmental mouse barrel cortex; n pairs in main text",
    "doi": "10.3390/cells14181459",
    "claim": "In developing mouse barrel cortex before the critical period, layer 2/3 horizontal connections between adjacent columns exhibit all-LTP STDP (pre-post and post-pre pairings both produce LTP), requiring NMDAR activation and PKA signalling, consistent with circuit-formation rules at L4→L2/3 and thalamocortical synapses during early development.",
    "cite_key": "Itami2025",
    "evidence": "Slice paired recordings between L2/3 pyramidal neurons of adjacent columns in developing mouse barrel cortex with pre-post and post-pre spike pairings, NMDAR (APV) and PKA (PKI 6-22) pharmacology.",
    "effect_size": "Both pairing orders elicit LTP; NMDAR- and PKA-dependent",
    "text_access": "fulltext",
    "study_system": "mouse barrel cortex, developmental slice paired recordings",
    "argument_role": "supporting",
    "replication_status": "consistent with unimodal STDP at developing thalamocortical and L4→L2/3 synapses",
    "claim_source_sentence": "we first show that the L2/3 horizontal connections exhibit all-LTP STDP when axons are extending during synapse formation before the critical period. LTP-STDP induced by pre-post timing was mediated by NMDA-R because APV blocked the induction. In addition, PKA signaling was involved because PKI 6-22 blocked the induction.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1016/j.celrep.2015.12.026"
    ],
    "effect_size_source_sentence": "the L2/3 horizontal connections exhibit all-LTP STDP when axons are extending during synapse formation before the critical period."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Both pairing orders elicit LTP; NMDAR- and PKA-dependent",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-7e9548acfa0a"
  ],
  "source_span": "we first show that the L2/3 horizontal connections exhibit all-LTP STDP when axons are extending during synapse formation before the critical period. LTP-STDP induced by pre-post timing was mediated by NMDA-R because APV blocked the induction. In addition, PKA signaling was involved because PKI 6-22 blocked the induction.",
  "study_system": "mouse barrel cortex, developmental slice paired recordings",
  "evidence_refs": [
    {
      "ref": "paper:paper-7e9548acfa0a"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Slice paired recordings between L2/3 pyramidal neurons of adjacent columns in developing mouse barrel cortex with pre-post and post-pre spike pairings, NMDAR (APV) and PKA (PKI 6-22) pharmacology.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "consistent with unimodal STDP at developing thalamocortical and L4→L2/3 synapses",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}