In developing mouse barrel cortex before the critical period, layer 2/3 horizon…

In developing mouse barrel cortex before the critical period, layer 2/3 horizontal connections between adjacent columns exhibit all-LTP STDP (pre-post and post-pre pairings both produce LTP), requiring NMDAR activation and PKA signalling, consistent with circuit-formation rules at L4→L2/3 and thalamocortical synapses during early development.

{
  "n": "developmental mouse barrel cortex; n pairs in main text",
  "doi": "10.3390/cells14181459",
  "claim": "In developing mouse barrel cortex before the critical period, layer 2/3 horizontal connections between adjacent columns exhibit all-LTP STDP (pre-post and post-pre pairings both produce LTP), requiring NMDAR activation and PKA signalling, consistent with circuit-formation rules at L4→L2/3 and thalamocortical synapses during early development.",
  "cite_key": "Itami2025",
  "evidence": "Slice paired recordings between L2/3 pyramidal neurons of adjacent columns in developing mouse barrel cortex with pre-post and post-pre spike pairings, NMDAR (APV) and PKA (PKI 6-22) pharmacology.",
  "effect_size": "Both pairing orders elicit LTP; NMDAR- and PKA-dependent",
  "text_access": "fulltext",
  "study_system": "mouse barrel cortex, developmental slice paired recordings",
  "argument_role": "supporting",
  "replication_status": "consistent with unimodal STDP at developing thalamocortical and L4→L2/3 synapses",
  "claim_source_sentence": "we first show that the L2/3 horizontal connections exhibit all-LTP STDP when axons are extending during synapse formation before the critical period. LTP-STDP induced by pre-post timing was mediated by NMDA-R because APV blocked the induction. In addition, PKA signaling was involved because PKI 6-22 blocked the induction.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1016/j.celrep.2015.12.026"
  ],
  "effect_size_source_sentence": "the L2/3 horizontal connections exhibit all-LTP STDP when axons are extending during synapse formation before the critical period."
}

[
  "paper:paper-7e9548acfa0a"
]

we first show that the L2/3 horizontal connections exhibit all-LTP STDP when axons are extending during synapse formation before the critical period. LTP-STDP induced by pre-post timing was mediated by NMDA-R because APV blocked the induction. In addition, PKA signaling was involved because PKI 6-22 blocked the induction.

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