Version history

{
  "scope": "human cortex, snRNA-seq, TSC patients",
  "claim_text": "In tuberous sclerosis complex (TSC) patient cortex, somatostatin-expressing (SST+) MGE-derived interneurons display an immature transcriptional signature including an abnormal NKCC1/KCC2 ratio, suggesting an incomplete excitatory-to-inhibitory GABAergic developmental switch — a CGE-vs-MGE lineage-selective vulnerability with implications for postnatal interneuron maturation.",
  "raw_fields": {
    "n": null,
    "doi": "10.1007/s00401-024-02737-7",
    "claim": "In tuberous sclerosis complex (TSC) patient cortex, somatostatin-expressing (SST+) MGE-derived interneurons display an immature transcriptional signature including an abnormal NKCC1/KCC2 ratio, suggesting an incomplete excitatory-to-inhibitory GABAergic developmental switch — a CGE-vs-MGE lineage-selective vulnerability with implications for postnatal interneuron maturation.",
    "title": null,
    "cite_key": "Scheper2024",
    "evidence": "Body, Results: single-nuclei RNA-seq in TSC patient cortical material, with cell-type-specific marker analysis of MGE- vs CGE-derived interneurons.",
    "effect_size": "MGE-derived SST+ subpopulation shows abnormal NKCC1/KCC2 ratio and downregulated GABA-A receptor subunits relative to controls",
    "text_access": "fulltext",
    "study_system": "human cortex, snRNA-seq, TSC patients",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single-study",
    "_source_cluster_index": 5,
    "claim_source_sentence": "The disrupted maturation of SST+ interneurons may undergo an incomplete switch from excitatory to inhibitory GABAergic signaling during development, resulting in reduced inhibitory properties.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Notably, this study reveals markers of immaturity specifically in SST+ interneurons, including an abnormal NKCC1/KCC2 ratio, indicating an imbalance in chloride homeostasis crucial for the postsynaptic consequences of GABAergic signaling as well as the downregulation of GABA A receptor subunits."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "MGE-derived SST+ subpopulation shows abnormal NKCC1/KCC2 ratio and downregulated GABA-A receptor subunits relative to controls",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-9a4f0475d0ca"
  ],
  "source_span": "The disrupted maturation of SST+ interneurons may undergo an incomplete switch from excitatory to inhibitory GABAergic signaling during development, resulting in reduced inhibitory properties.",
  "study_system": "human cortex, snRNA-seq, TSC patients",
  "evidence_refs": [
    {
      "ref": "paper:paper-9a4f0475d0ca"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Body, Results: single-nuclei RNA-seq in TSC patient cortical material, with cell-type-specific marker analysis of MGE- vs CGE-derived interneurons.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}