Version history

{
  "scope": "mouse primary visual cortex, in vivo two-photon imaging",
  "claim_text": "Locomotion increases activity of VIP, SST, and PV interneurons during visual stimulation in V1, challenging the simple disinhibition model of locomotion-induced gain",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.14985",
    "claim": "Locomotion increases activity of VIP, SST, and PV interneurons during visual stimulation in V1, challenging the simple disinhibition model of locomotion-induced gain",
    "evidence": "In vivo two-photon calcium imaging in layers 2/3 and 4 of mouse V1 during locomotion and visual stimulation",
    "effect_size": "All three interneuron types increased activity during locomotion with visual stimulation; SST and excitatory neurons non-responsive in darkness",
    "text_access": "fulltext",
    "study_system": "mouse primary visual cortex, in vivo two-photon imaging",
    "replication_status": "single study",
    "claim_source_sentence": "We reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "In darkness, while most VIP and PV neurons remained locomotion responsive, SST and excitatory neurons were largely non-responsive."
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "effect_size": "All three interneuron types increased activity during locomotion with visual stimulation; SST and excitatory neurons non-responsive in darkness",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-acf576c0a2ed"
  ],
  "source_span": "We reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model.",
  "study_system": "mouse primary visual cortex, in vivo two-photon imaging",
  "evidence_refs": [
    {
      "ref": "paper:paper-acf576c0a2ed"
    }
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "In vivo two-photon calcium imaging in layers 2/3 and 4 of mouse V1 during locomotion and visual stimulation",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "single study",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}