- claim_text
In mouse forelimb S1, cortico-thalamo-cortical excitatory circuits formed by L6 corticothalamic and L5B pyramidal-tract neurons project preferentially to thalamocortical neurons that project back to the same cortical area — a recurrent-loop architecture.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.2277-19.2020",
"claim": "In mouse forelimb S1, cortico-thalamo-cortical excitatory circuits formed by L6 corticothalamic and L5B pyramidal-tract neurons project preferentially to thalamocortical neurons that project back to the same cortical area — a recurrent-loop architecture.",
"cite_key": "Guo2020",
"evidence": "Cell-type-specific anterograde optogenetic excitation with single-cell recordings from retrogradely labeled thalamocortical neurons in mouse forelimb S1.",
"effect_size": "Strongest excitatory input to TC neurons projecting back to the same cortical area.",
"text_access": "abstract_only",
"study_system": "mouse forelimb primary somatosensory cortex (S1); L6CT and L5B PT projection neurons; opto-circuit dissection",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "The CT neurons in S1 synaptically excited S1-projecting thalamocortical (TC) neurons in subregions of both the ventral posterior lateral and posterior (PO) nuclei, forming a pair of recurrent cortico-thalamo-cortical (C-T-C) loops. The PT neurons in S1 also formed a recurrent loop with S1-projecting TC neurons in the same subregion of the PO.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-7c6266401771"
]
- source_span
The CT neurons in S1 synaptically excited S1-projecting thalamocortical (TC) neurons in subregions of both the ventral posterior lateral and posterior (PO) nuclei, forming a pair of recurrent cortico-thalamo-cortical (C-T-C) loops. The PT neurons in S1 also formed a recurrent loop with S1-projecting TC neurons in the same subregion of the PO.
- evidence_refs
[
{
"ref": "paper:paper-7c6266401771"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}