Version history

{
  "scope": "mouse (whole-brain serial two-photon tomography)",
  "claim_text": "A two-photon block-face fluorescence imaging platform integrated with a vibratome enables whole-brain visualization and reconstruction of complete long-range axonal arbors at sub-micron resolution.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.10566",
    "claim": "A two-photon block-face fluorescence imaging platform integrated with a vibratome enables whole-brain visualization and reconstruction of complete long-range axonal arbors at sub-micron resolution.",
    "cite_key": "Economo2016",
    "evidence": "Demonstrated reconstruction of axonal arbors of multiple mouse motor-cortex neurons across an entire brain, with axon detection down to ~100 nm diameter.",
    "effect_size": "Axon diameters as small as 100 nm visualized; arbors spanning many millimeters reconstructed",
    "text_access": "fulltext",
    "study_system": "mouse (whole-brain serial two-photon tomography)",
    "source_cluster_id": "cluster_03",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We have developed an imaging system for whole-brain, high-resolution fluorescence imaging and demonstrate that this approach can be used to trace individual axonal fibers and fine axon collater- als across the brain to their termini ( Video 2 ) and thereby map the long-distance projections of sin- gle neurons ( Figure 6 ).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "However, the arbors of very few long-range projection neurons have been reconstructed in their entirety, as axons with diameters as small as 100 nm arborize in target regions dispersed over many millimeters of tissue."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "effect_size": "Axon diameters as small as 100 nm visualized; arbors spanning many millimeters reconstructed",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:b99d7c4a-9270-42c0-b083-2109f9c1eabf"
  ],
  "source_span": "We have developed an imaging system for whole-brain, high-resolution fluorescence imaging and demonstrate that this approach can be used to trace individual axonal fibers and fine axon collater- als across the brain to their termini ( Video 2 ) and thereby map the long-distance projections of sin- gle neurons ( Figure 6 ).",
  "study_system": "mouse (whole-brain serial two-photon tomography)",
  "evidence_refs": [
    {
      "ref": "paper:b99d7c4a-9270-42c0-b083-2109f9c1eabf"
    }
  ],
  "section_title": "The Cortico-Striatal Interface: Topography, Cell Types, and Input Convergence",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Demonstrated reconstruction of axonal arbors of multiple mouse motor-cortex neurons across an entire brain, with axon detection down to ~100 nm diameter.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}