Version history

{
  "scope": "multi-compartment computational models of hippocampal VIP+ IS3 cells",
  "claim_text": "Multi-compartment computational models of hippocampal VIP+ IS3 cells predict that balanced excitation and inhibition (with low numbers of correlated synapses) produce asynchronous in-vivo-like states sensitive to 8-Hz theta-timed inputs, generating strongly increased theta-band spectral power.",
  "raw_fields": {
    "n": null,
    "doi": "10.1371/journal.pone.0209429",
    "pmid": "30620732",
    "year": "2019",
    "claim": "Multi-compartment computational models of hippocampal VIP+ IS3 cells predict that balanced excitation and inhibition (with low numbers of correlated synapses) produce asynchronous in-vivo-like states sensitive to 8-Hz theta-timed inputs, generating strongly increased theta-band spectral power.",
    "pmcid": "PMC6324795",
    "title": "Using computational models to predict in vivo synaptic inputs to interneuron specific 3 (IS3) cells of CA1 hippocampus that also allow their recruitment during rhythmic states.",
    "authors": "",
    "journal": "",
    "cite_key": "Guetmccreight2019",
    "evidence": "Large-scale parameter exploration of multi-compartment IS3 models with optimized synaptic conductances and 8-Hz layer-specific inputs.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "theta-timed inputs increase spectral power; balanced conductances yield asynchronous baseline state",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "multi-compartment computational models of hippocampal VIP+ IS3 cells",
    "cited_by_count": 16,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "single-study",
    "_source_cluster_index": 9,
    "claim_source_sentence": "We find that asynchronous, in vivo-like states that are sensitive to additional theta-timed inputs (8 Hz) exist when excitatory and inhibitory synaptic conductances are approximately equally balanced and with low numbers of activated synapses receiving correlated inputs. Incoming theta-timed inputs result in strongly increased spectral power relative to baseline.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Incoming theta-timed inputs result in strongly increased spectral power relative to baseline."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "theta-timed inputs increase spectral power; balanced conductances yield asynchronous baseline state",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-179aeabaffe8"
  ],
  "source_span": "We find that asynchronous, in vivo-like states that are sensitive to additional theta-timed inputs (8 Hz) exist when excitatory and inhibitory synaptic conductances are approximately equally balanced and with low numbers of activated synapses receiving correlated inputs. Incoming theta-timed inputs result in strongly increased spectral power relative to baseline.",
  "study_system": "multi-compartment computational models of hippocampal VIP+ IS3 cells",
  "evidence_refs": [
    {
      "ref": "paper:paper-179aeabaffe8"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Large-scale parameter exploration of multi-compartment IS3 models with optimized synaptic conductances and 8-Hz layer-specific inputs.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}