Multi-compartment computational models of hippocampal VIP+ IS3 cells predict th…

Multi-compartment computational models of hippocampal VIP+ IS3 cells predict that balanced excitation and inhibition (with low numbers of correlated synapses) produce asynchronous in-vivo-like states sensitive to 8-Hz theta-timed inputs, generating strongly increased theta-band spectral power.

{
  "n": null,
  "doi": "10.1371/journal.pone.0209429",
  "pmid": "30620732",
  "year": "2019",
  "claim": "Multi-compartment computational models of hippocampal VIP+ IS3 cells predict that balanced excitation and inhibition (with low numbers of correlated synapses) produce asynchronous in-vivo-like states sensitive to 8-Hz theta-timed inputs, generating strongly increased theta-band spectral power.",
  "pmcid": "PMC6324795",
  "title": "Using computational models to predict in vivo synaptic inputs to interneuron specific 3 (IS3) cells of CA1 hippocampus that also allow their recruitment during rhythmic states.",
  "authors": "",
  "journal": "",
  "cite_key": "Guetmccreight2019",
  "evidence": "Large-scale parameter exploration of multi-compartment IS3 models with optimized synaptic conductances and 8-Hz layer-specific inputs.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "theta-timed inputs increase spectral power; balanced conductances yield asynchronous baseline state",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "multi-compartment computational models of hippocampal VIP+ IS3 cells",
  "cited_by_count": 16,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 9,
  "claim_source_sentence": "We find that asynchronous, in vivo-like states that are sensitive to additional theta-timed inputs (8 Hz) exist when excitatory and inhibitory synaptic conductances are approximately equally balanced and with low numbers of activated synapses receiving correlated inputs. Incoming theta-timed inputs result in strongly increased spectral power relative to baseline.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Incoming theta-timed inputs result in strongly increased spectral power relative to baseline."
}

[
  "paper:paper-179aeabaffe8"
]

We find that asynchronous, in vivo-like states that are sensitive to additional theta-timed inputs (8 Hz) exist when excitatory and inhibitory synaptic conductances are approximately equally balanced and with low numbers of activated synapses receiving correlated inputs. Incoming theta-timed inputs result in strongly increased spectral power relative to baseline.

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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