Version history

{
  "scope": "Mouse V1, anesthetized; 2P holographic optogenetics + whole-cell recording + compressive sensing",
  "claim_text": "High-throughput two-photon holographic optogenetic mapping of E→E connectivity in mouse V1 reveals synaptic pair identities and strengths across ~100 potential presynaptic neurons in ~5 min, supporting quantitative characterization of cortical recurrent excitatory connectivity in vivo.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41593-025-02024-y",
    "claim": "High-throughput two-photon holographic optogenetic mapping of E→E connectivity in mouse V1 reveals synaptic pair identities and strengths across ~100 potential presynaptic neurons in ~5 min, supporting quantitative characterization of cortical recurrent excitatory connectivity in vivo.",
    "cite_key": "Chen2025b",
    "evidence": "Combined two-photon holographic single-cell optogenetic stimulation, whole-cell patch-clamp postsynaptic recording, and compressive-sensing reconstruction in anesthetized mouse V1.",
    "effect_size": "up to 100 presynaptic candidates probed per 5 min; up to threefold reduction in measurements via compressive sensing",
    "text_access": "abstract_only",
    "study_system": "Mouse V1, anesthetized; 2P holographic optogenetics + whole-cell recording + compressive sensing",
    "argument_role": "supporting",
    "replication_status": "within_lab",
    "claim_source_sentence": "Under sequential single-cell stimulation, the method enables rapid probing of connectivity across up to 100 potential presynaptic cells within ~5 min in the visual cortex of anesthetized mice, identifying synaptic pairs along with their strength and spatial distribution.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Under sequential single-cell stimulation, the method enables rapid probing of connectivity across up to 100 potential presynaptic cells within ~5 min in the visual cortex of anesthetized mice, identifying synaptic pairs along with their strength and spatial distribution."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "up to 100 presynaptic candidates probed per 5 min; up to threefold reduction in measurements via compressive sensing",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-218c7dbe65b1"
  ],
  "source_span": "Under sequential single-cell stimulation, the method enables rapid probing of connectivity across up to 100 potential presynaptic cells within ~5 min in the visual cortex of anesthetized mice, identifying synaptic pairs along with their strength and spatial distribution.",
  "study_system": "Mouse V1, anesthetized; 2P holographic optogenetics + whole-cell recording + compressive sensing",
  "evidence_refs": [
    {
      "ref": "paper:paper-218c7dbe65b1"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Combined two-photon holographic single-cell optogenetic stimulation, whole-cell patch-clamp postsynaptic recording, and compressive-sensing reconstruction in anesthetized mouse V1.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "within_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}