- claim_text
High-throughput two-photon holographic optogenetic mapping of E→E connectivity in mouse V1 reveals synaptic pair identities and strengths across ~100 potential presynaptic neurons in ~5 min, supporting quantitative characterization of cortical recurrent excitatory connectivity in vivo.
- raw_fields
{
"n": 0,
"doi": "10.1038/s41593-025-02024-y",
"claim": "High-throughput two-photon holographic optogenetic mapping of E→E connectivity in mouse V1 reveals synaptic pair identities and strengths across ~100 potential presynaptic neurons in ~5 min, supporting quantitative characterization of cortical recurrent excitatory connectivity in vivo.",
"cite_key": "Chen2025b",
"evidence": "Combined two-photon holographic single-cell optogenetic stimulation, whole-cell patch-clamp postsynaptic recording, and compressive-sensing reconstruction in anesthetized mouse V1.",
"effect_size": "up to 100 presynaptic candidates probed per 5 min; up to threefold reduction in measurements via compressive sensing",
"text_access": "abstract_only",
"study_system": "Mouse V1, anesthetized; 2P holographic optogenetics + whole-cell recording + compressive sensing",
"argument_role": "supporting",
"replication_status": "within_lab",
"claim_source_sentence": "Under sequential single-cell stimulation, the method enables rapid probing of connectivity across up to 100 potential presynaptic cells within ~5 min in the visual cortex of anesthetized mice, identifying synaptic pairs along with their strength and spatial distribution.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Under sequential single-cell stimulation, the method enables rapid probing of connectivity across up to 100 potential presynaptic cells within ~5 min in the visual cortex of anesthetized mice, identifying synaptic pairs along with their strength and spatial distribution."
}- source_refs
[
"paper:paper-218c7dbe65b1"
]
- source_span
Under sequential single-cell stimulation, the method enables rapid probing of connectivity across up to 100 potential presynaptic cells within ~5 min in the visual cortex of anesthetized mice, identifying synaptic pairs along with their strength and spatial distribution.
- evidence_refs
[
{
"ref": "paper:paper-218c7dbe65b1"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}