Version history

{
  "scope": "mouse secondary motor cortex (M2) L5 IT pyramidal neurons; sparse single-cell reconstruction",
  "claim_text": "In mouse secondary motor cortex (M2), layer-5 intratelencephalic (IT) cells comprise distinct subtypes with differential L1 innervation preference: 'L1-preferring' IT cells more frequently express ER81 and project to a larger set of cortical areas than IT cells with low L1 preference, demonstrating projection-class heterogeneity within L5 corticocortical feedback.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1093/cercor/bhac052",
    "claim": "In mouse secondary motor cortex (M2), layer-5 intratelencephalic (IT) cells comprise distinct subtypes with differential L1 innervation preference: 'L1-preferring' IT cells more frequently express ER81 and project to a larger set of cortical areas than IT cells with low L1 preference, demonstrating projection-class heterogeneity within L5 corticocortical feedback.",
    "cite_key": "Im2022",
    "evidence": "Single-cell labeling, intersectional genetic tagging (ER81), and whole-brain axon reconstruction of identified M2 L5 IT pyramidal neurons in mouse; quantification of L1-vs-other-layer axon density and cortical target counts per cell.",
    "effect_size": "L1-preferring IT subtype projects to more cortical areas than low-L1-preference IT cells",
    "text_access": "fulltext",
    "study_system": "mouse secondary motor cortex (M2) L5 IT pyramidal neurons; sparse single-cell reconstruction",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "Our results show that IT cells that preferentially innervate L1, an important target of feedback projections, more frequently express ER81 and project to a greater number of cortical areas than do IT cells with lower preference for L1.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.34133/research.0470"
    ],
    "effect_size_source_sentence": "The cells with lower L1 axon ratio were larger in CV and sent axonal projections to limited regions, such as M1 (left graphs)."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "L1-preferring IT subtype projects to more cortical areas than low-L1-preference IT cells",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-e55711a2961a"
  ],
  "source_span": "Our results show that IT cells that preferentially innervate L1, an important target of feedback projections, more frequently express ER81 and project to a greater number of cortical areas than do IT cells with lower preference for L1.",
  "study_system": "mouse secondary motor cortex (M2) L5 IT pyramidal neurons; sparse single-cell reconstruction",
  "evidence_refs": [
    {
      "ref": "paper:paper-e55711a2961a"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Single-cell labeling, intersectional genetic tagging (ER81), and whole-brain axon reconstruction of identified M2 L5 IT pyramidal neurons in mouse; quantification of L1-vs-other-layer axon density and cortical target counts per cell.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}