In mouse secondary motor cortex (M2), layer-5 intratelencephalic (IT) cells com…

In mouse secondary motor cortex (M2), layer-5 intratelencephalic (IT) cells comprise distinct subtypes with differential L1 innervation preference: 'L1-preferring' IT cells more frequently express ER81 and project to a larger set of cortical areas than IT cells with low L1 preference, demonstrating projection-class heterogeneity within L5 corticocortical feedback.

{
  "n": 0,
  "doi": "10.1093/cercor/bhac052",
  "claim": "In mouse secondary motor cortex (M2), layer-5 intratelencephalic (IT) cells comprise distinct subtypes with differential L1 innervation preference: 'L1-preferring' IT cells more frequently express ER81 and project to a larger set of cortical areas than IT cells with low L1 preference, demonstrating projection-class heterogeneity within L5 corticocortical feedback.",
  "cite_key": "Im2022",
  "evidence": "Single-cell labeling, intersectional genetic tagging (ER81), and whole-brain axon reconstruction of identified M2 L5 IT pyramidal neurons in mouse; quantification of L1-vs-other-layer axon density and cortical target counts per cell.",
  "effect_size": "L1-preferring IT subtype projects to more cortical areas than low-L1-preference IT cells",
  "text_access": "fulltext",
  "study_system": "mouse secondary motor cortex (M2) L5 IT pyramidal neurons; sparse single-cell reconstruction",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Our results show that IT cells that preferentially innervate L1, an important target of feedback projections, more frequently express ER81 and project to a greater number of cortical areas than do IT cells with lower preference for L1.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.34133/research.0470"
  ],
  "effect_size_source_sentence": "The cells with lower L1 axon ratio were larger in CV and sent axonal projections to limited regions, such as M1 (left graphs)."
}

[
  "paper:paper-e55711a2961a"
]

[
  {
    "ref": "paper:paper-e55711a2961a"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}