- claim_text
Mediodorsal thalamic neurons projecting to mouse medial prefrontal cortex occupy two subdivisions (MD-medial and MD-lateral) with distinct intrinsic physiology: MD-L→mPFC cells have shorter membrane time constants, lower input resistance and higher rheobase than MD-M→mPFC cells, driven by stronger HCN channel activity in MD-L.
- raw_fields
{
"n": null,
"doi": "10.1152/jn.00456.2023",
"claim": "Mediodorsal thalamic neurons projecting to mouse medial prefrontal cortex occupy two subdivisions (MD-medial and MD-lateral) with distinct intrinsic physiology: MD-L→mPFC cells have shorter membrane time constants, lower input resistance and higher rheobase than MD-M→mPFC cells, driven by stronger HCN channel activity in MD-L.",
"cite_key": "Lyuboslavsky2024",
"evidence": "CTB retrograde tracing from mPFC plus acute-slice current-clamp recordings of identified MD→mPFC neurons in adult wild-type mice.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse mediodorsal thalamus → mPFC projection neurons, acute slice electrophysiology",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "MD-L→mPFC neurons had shorter membrane time constants and lower membrane resistance than MD-M→mPFC neurons. Relatively increased hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity in MD-L neurons accounted for the difference in membrane resistance. MD-L neurons had a higher rheobase that resulted in less readily generated action potentials compared with MD-M→mPFC neurons.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:5659cfc2-617d-4c9c-bb1d-086332165d03"
]
- source_span
MD-L→mPFC neurons had shorter membrane time constants and lower membrane resistance than MD-M→mPFC neurons. Relatively increased hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity in MD-L neurons accounted for the difference in membrane resistance. MD-L neurons had a higher rheobase that resulted in less readily generated action potentials compared with MD-M→mPFC neurons.
- evidence_refs
[
{
"ref": "paper:5659cfc2-617d-4c9c-bb1d-086332165d03"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}