Version history

{
  "scope": "Adult mouse primary visual cortex; ex vivo slice patch clamp + biocytin; multiple Cre/Flp transgenic lines",
  "claim_text": "Allen Institute Patch-clamp/biocytin morphology pipeline of adult mouse visual cortex established a taxonomy of 17 e-types, 38 m-types, and 46 me-types, with good correspondence to transcriptomic subclasses (Lamp5, Sncg, Vip, Sst, Pvalb).",
  "raw_fields": {
    "n": 1938,
    "doi": "10.1038/s41593-019-0417-0",
    "claim": "Allen Institute Patch-clamp/biocytin morphology pipeline of adult mouse visual cortex established a taxonomy of 17 e-types, 38 m-types, and 46 me-types, with good correspondence to transcriptomic subclasses (Lamp5, Sncg, Vip, Sst, Pvalb).",
    "title": null,
    "cite_key": "Gouwens2019",
    "evidence": "Standardised whole-cell patch clamp + biocytin reconstructions in adult mouse visual cortex; unsupervised clustering of morphological and electrophysiological features; cross-validation with transgenic mouse line identity matched to transcriptomic subclasses.",
    "effect_size": "1,938 neurons electrophysiology; 461 reconstructed; 452 with both",
    "text_access": "fulltext",
    "study_system": "Adult mouse primary visual cortex; ex vivo slice patch clamp + biocytin; multiple Cre/Flp transgenic lines",
    "_source_cluster": "cluster_03_morphology",
    "replication_status": "replicated",
    "_source_cluster_index": 34,
    "claim_source_sentence": "We established a taxonomy of morphologically- and electrophysiologically-defined cell types for this region of cortex with 17 e-types, 38 m-types, and 46 me-types and found good correspondence with previously-defined transcriptomic cell types and subclasses using the same transgenic mouse lines.",
    "replication_evidence_dois": [
      "10.1038/s41593-020-0685-8",
      "10.1038/s41586-020-2907-3",
      "10.1016/j.cell.2020.09.057"
    ],
    "effect_size_source_sentence": "Intrinsic physiological properties were measured from 1,938 neurons from the adult laboratory mouse visual cortex, morphological properties were measured from 461 reconstructed neurons, and 452 neurons had both measurements available."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_04_evidence_package.json",
  "effect_size": "1,938 neurons electrophysiology; 461 reconstructed; 452 with both",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-04-morphology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-b9e0351c6ddd"
  ],
  "source_span": "We established a taxonomy of morphologically- and electrophysiologically-defined cell types for this region of cortex with 17 e-types, 38 m-types, and 46 me-types and found good correspondence with previously-defined transcriptomic cell types and subclasses using the same transgenic mouse lines.",
  "study_system": "Adult mouse primary visual cortex; ex vivo slice patch clamp + biocytin; multiple Cre/Flp transgenic lines",
  "evidence_refs": [
    {
      "ref": "paper:paper-b9e0351c6ddd"
    }
  ],
  "section_title": "Morphological Diversity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Standardised whole-cell patch clamp + biocytin reconstructions in adult mouse visual cortex; unsupervised clustering of morphological and electrophysiological features; cross-validation with transgenic mouse line identity matched to transcriptomic subclasses.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-04-morphology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_04_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}