Details
- scope
- Adult mouse primary visual cortex; ex vivo slice patch clamp + biocytin; multiple Cre/Flp transgenic lines
- claim_text
- Allen Institute Patch-clamp/biocytin morphology pipeline of adult mouse visual cortex established a taxonomy of 17 e-types, 38 m-types, and 46 me-types, with good correspondence to transcriptomic subclasses (Lamp5, Sncg, Vip, Sst, Pvalb).
- section_id
- section_04
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_04_evidence_package.json
- effect_size
- 1,938 neurons electrophysiology; 461 reconstructed; 452 with both
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-04-morphology
- source_kind
- review_finding
- source_path
- evidence/section_04_evidence_package.json
- study_system
- Adult mouse primary visual cortex; ex vivo slice patch clamp + biocytin; multiple Cre/Flp transgenic lines
- section_title
- Morphological Diversity
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-04-morphology
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_04_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (6)
- raw_fields
{ "n": 1938, "doi": "10.1038/s41593-019-0417-0", "claim": "Allen Institute Patch-clamp/biocytin morphology pipeline of adult mouse visual cortex established a taxonomy of 17 e-types, 38 m-types, and 46 me-types, with good correspondence to transcriptomic subclasses (Lamp5, Sncg, Vip, Sst, Pvalb).", "title": null, "cite_key": "Gouwens2019", "evidence": "Standardised whole-cell patch clamp + biocytin reconstructions in adult mouse visual cortex; unsupervised clustering of morphological and electrophysiological features; cross-validation with transgenic mouse line identity matched to transcriptomic subclasses.", "effect_size": "1,938 neurons electrophysiology; 461 reconstructed; 452 with both", "text_access": "fulltext", "study_system": "Adult mouse primary visual cortex; ex vivo slice patch clamp + biocytin; multiple Cre/Flp transgenic lines", "_source_cluster": "cluster_03_morphology", "replication_status": "replicated", "_source_cluster_index": 34, "claim_source_sentence": "We established a taxonomy of morphologically- and electrophysiologically-defined cell types for this region of cortex with 17 e-types, 38 m-types, and 46 me-types and found good correspondence with previously-defined transcriptomic cell types and subclasses using the same transgenic mouse lines.", "replication_evidence_dois": [ "10.1038/s41593-020-0685-8", "10.1038/s41586-020-2907-3", "10.1016/j.cell.2020.09.057" ], "effect_size_source_sentence": "Intrinsic physiological properties were measured from 1,938 neurons from the adult laboratory mouse visual cortex, morphological properties were measured from 461 reconstructed neurons, and 452 neurons had both measurements available." }- source_refs
[ "paper:paper-b9e0351c6ddd" ]
- source_span
We established a taxonomy of morphologically- and electrophysiologically-defined cell types for this region of cortex with 17 e-types, 38 m-types, and 46 me-types and found good correspondence with previously-defined transcriptomic cell types and subclasses using the same transgenic mouse lines.
- evidence_refs
[ { "ref": "paper:paper-b9e0351c6ddd" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }- evidence_summary
Standardised whole-cell patch clamp + biocytin reconstructions in adult mouse visual cortex; unsupervised clustering of morphological and electrophysiological features; cross-validation with transgenic mouse line identity matched to transcriptomic subclasses.