- raw_fields
{
"n": null,
"doi": "10.1113/jp287265",
"claim": "Optogenetic tools have been used to investigate neural circuits in mouse primary visual cortex (V1), where channelrhodopsin-mediated activation (photostimulation) of inhibitory interneuron subtypes e…",
"cite_key": "Shapiro2025",
"evidence": "Optogenetic tools have been used to investigate neural circuits in mouse primary visual cortex (V1), where channelrhodopsin-mediated activation (photostimulation) of inhibitory interneuron subtypes expressing parvalbumin (Pvalb+), somatostatin (SOM+) or vasoactive intestinal peptide (VIP+) can alter the responses of excitatory pyramidal neurons. Some studies have mentioned rebound spiking after this photostimulation, but no systematic analysis of these post-inhibitory rebound effects has yet bee...",
"effect_size": "Pyr cells (black triangles) use excitatory glutamatergic chemical synapses (Excite) to activate interneurons with feedforward (FF) or feedback (FB) connections., spike density function (SDF) and raster plot showing a Pvalb+ interneuron's response to a drifting 100% contrast sine wave grating without (black line) or with optogenetic activation (red line).",
"text_access": "fulltext",
"study_system": "mouse; V1, visual cortex; optogenetics; The Journal of physiology",
"argument_role": "supporting",
"replication_status": "single_study",
"claim_source_sentence": "Optogenetic tools have been used to investigate neural circuits in mouse primary visual cortex (V1), where channelrhodopsin-mediated activation (photostimulation) of inhibitory interneuron subtypes expressing parvalbumin (Pvalb+), somatostatin (SOM+) or vasoactive intestinal peptide (VIP+) can alter the responses of excitatory pyramidal neurons.",
"source_provenance_status": "ok",
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"effect_size_source_sentence": "Pyr cells (black triangles) use excitatory glutamatergic chemical synapses (Excite) to activate interneurons with feedforward (FF) or feedback (FB) connections., spike density function (SDF) and raster plot showing a Pvalb+ interneuron's response to a drifting 100% contrast sine wave grating without (black line) or with optogenetic activation (red line)."
}- effect_size
Pyr cells (black triangles) use excitatory glutamatergic chemical synapses (Excite) to activate interneurons with feedforward (FF) or feedback (FB) connections., spike density function (SDF) and raster plot showing a Pvalb+ interneuron's response to a drifting 100% contrast sine wave grating without (black line) or with optogenetic activation (red line).
- source_refs
[
"paper:paper-410b852f3cc3"
]
- source_span
Optogenetic tools have been used to investigate neural circuits in mouse primary visual cortex (V1), where channelrhodopsin-mediated activation (photostimulation) of inhibitory interneuron subtypes expressing parvalbumin (Pvalb+), somatostatin (SOM+) or vasoactive intestinal peptide (VIP+) can alter the responses of excitatory pyramidal neurons.
- evidence_refs
[
{
"ref": "paper:paper-410b852f3cc3"
}
]- source_policy
{
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"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
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"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
Optogenetic tools have been used to investigate neural circuits in mouse primary visual cortex (V1), where channelrhodopsin-mediated activation (photostimulation) of inhibitory interneuron subtypes expressing parvalbumin (Pvalb+), somatostatin (SOM+) or vasoactive intestinal peptide (VIP+) can alter the responses of excitatory pyramidal neurons. Some studies have mentioned rebound spiking after this photostimulation, but no systematic analysis of these post-inhibitory rebound effects has yet bee...