Version history

{
  "scope": "mouse; V1, visual cortex; optogenetics; The Journal of physiology",
  "claim_text": "Optogenetic tools have been used to investigate neural circuits in mouse primary visual cortex (V1), where channelrhodopsin-mediated activation (photostimulation) of inhibitory interneuron subtypes e…",
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    "doi": "10.1113/jp287265",
    "claim": "Optogenetic tools have been used to investigate neural circuits in mouse primary visual cortex (V1), where channelrhodopsin-mediated activation (photostimulation) of inhibitory interneuron subtypes e…",
    "cite_key": "Shapiro2025",
    "evidence": "Optogenetic tools have been used to investigate neural circuits in mouse primary visual cortex (V1), where channelrhodopsin-mediated activation (photostimulation) of inhibitory interneuron subtypes expressing parvalbumin (Pvalb+), somatostatin (SOM+) or vasoactive intestinal peptide (VIP+) can alter the responses of excitatory pyramidal neurons. Some studies have mentioned rebound spiking after this photostimulation, but no systematic analysis of these post-inhibitory rebound effects has yet bee...",
    "effect_size": "Pyr cells (black triangles) use excitatory glutamatergic chemical synapses (Excite) to activate interneurons with feedforward (FF) or feedback (FB) connections., spike density function (SDF) and raster plot showing a Pvalb+ interneuron's response to a drifting 100% contrast sine wave grating without (black line) or with optogenetic activation (red line).",
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    "effect_size_source_sentence": "Pyr cells (black triangles) use excitatory glutamatergic chemical synapses (Excite) to activate interneurons with feedforward (FF) or feedback (FB) connections., spike density function (SDF) and raster plot showing a Pvalb+ interneuron's response to a drifting 100% contrast sine wave grating without (black line) or with optogenetic activation (red line)."
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  "effect_size": "Pyr cells (black triangles) use excitatory glutamatergic chemical synapses (Excite) to activate interneurons with feedforward (FF) or feedback (FB) connections., spike density function (SDF) and raster plot showing a Pvalb+ interneuron's response to a drifting 100% contrast sine wave grating without (black line) or with optogenetic activation (red line).",
  "review_repo": "ComputationalReviewRecurrence",
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  "study_system": "mouse; V1, visual cortex; optogenetics; The Journal of physiology",
  "evidence_refs": [
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  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
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  "evidence_summary": "Optogenetic tools have been used to investigate neural circuits in mouse primary visual cortex (V1), where channelrhodopsin-mediated activation (photostimulation) of inhibitory interneuron subtypes expressing parvalbumin (Pvalb+), somatostatin (SOM+) or vasoactive intestinal peptide (VIP+) can alter the responses of excitatory pyramidal neurons. Some studies have mentioned rebound spiking after this photostimulation, but no systematic analysis of these post-inhibitory rebound effects has yet bee...",
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