Version history

{
  "scope": "mouse higher visual areas LM/AL/PM/AM, V1-axon-driven input",
  "claim_text": "Whole-cell recordings in mouse higher visual areas (LM, AL, PM, AM) with optogenetic V1-axon stimulation show area-specific differences in the strength of recruitment of inhibitory interneurons through feed-forward vs recurrent pathways, as well as area-specific differences in cell-intrinsic excitability and interneuron density — with the most striking medial-vs-lateral differences — establishing that HVAs differ not just in input but in intrinsic circuit motifs that determine net excitability and V1-input integration.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.cub.2021.09.042",
    "claim": "Whole-cell recordings in mouse higher visual areas (LM, AL, PM, AM) with optogenetic V1-axon stimulation show area-specific differences in the strength of recruitment of inhibitory interneurons through feed-forward vs recurrent pathways, as well as area-specific differences in cell-intrinsic excitability and interneuron density — with the most striking medial-vs-lateral differences — establishing that HVAs differ not just in input but in intrinsic circuit motifs that determine net excitability and V1-input integration.",
    "cite_key": "Li2021a",
    "evidence": "Whole-cell patch-clamp recording with V1-Channelrhodopsin axon stimulation in slices of mouse LM, AL, PM, AM.",
    "effect_size": "qualitative — area-specific HVA circuit motifs beyond input",
    "text_access": "fulltext",
    "study_system": "mouse higher visual areas LM/AL/PM/AM, V1-axon-driven input",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "area-specific differences in the strength of recruitment of interneurons through feed-forward and recurrent pathways, as well as differences in cell-intrinsic properties and interneuron densities. These differences were most striking when comparing across medial and lateral areas",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "area-specific differences in the strength of recruitment of interneurons through feed-forward and recurrent pathways"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — area-specific HVA circuit motifs beyond input",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-21937e5a070f"
  ],
  "source_span": "area-specific differences in the strength of recruitment of interneurons through feed-forward and recurrent pathways, as well as differences in cell-intrinsic properties and interneuron densities. These differences were most striking when comparing across medial and lateral areas",
  "study_system": "mouse higher visual areas LM/AL/PM/AM, V1-axon-driven input",
  "evidence_refs": [
    {
      "ref": "paper:paper-21937e5a070f"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Whole-cell patch-clamp recording with V1-Channelrhodopsin axon stimulation in slices of mouse LM, AL, PM, AM.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}