Whole-cell recordings in mouse higher visual areas (LM, AL, PM, AM) with optoge…

Whole-cell recordings in mouse higher visual areas (LM, AL, PM, AM) with optogenetic V1-axon stimulation show area-specific differences in the strength of recruitment of inhibitory interneurons through feed-forward vs recurrent pathways, as well as area-specific differences in cell-intrinsic excitability and interneuron density — with the most striking medial-vs-lateral differences — establishing that HVAs differ not just in input but in intrinsic circuit motifs that determine net excitability and V1-input integration.

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  "n": 0,
  "doi": "10.1016/j.cub.2021.09.042",
  "claim": "Whole-cell recordings in mouse higher visual areas (LM, AL, PM, AM) with optogenetic V1-axon stimulation show area-specific differences in the strength of recruitment of inhibitory interneurons through feed-forward vs recurrent pathways, as well as area-specific differences in cell-intrinsic excitability and interneuron density — with the most striking medial-vs-lateral differences — establishing that HVAs differ not just in input but in intrinsic circuit motifs that determine net excitability and V1-input integration.",
  "cite_key": "Li2021a",
  "evidence": "Whole-cell patch-clamp recording with V1-Channelrhodopsin axon stimulation in slices of mouse LM, AL, PM, AM.",
  "effect_size": "qualitative — area-specific HVA circuit motifs beyond input",
  "text_access": "fulltext",
  "study_system": "mouse higher visual areas LM/AL/PM/AM, V1-axon-driven input",
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  "claim_source_sentence": "area-specific differences in the strength of recruitment of interneurons through feed-forward and recurrent pathways, as well as differences in cell-intrinsic properties and interneuron densities. These differences were most striking when comparing across medial and lateral areas",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "area-specific differences in the strength of recruitment of interneurons through feed-forward and recurrent pathways"
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area-specific differences in the strength of recruitment of interneurons through feed-forward and recurrent pathways, as well as differences in cell-intrinsic properties and interneuron densities. These differences were most striking when comparing across medial and lateral areas

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