Version history

{
  "scope": "macaque dorsolateral prefrontal cortex, in vivo iontophoresis",
  "claim_text": "Beta1-adrenoceptors are expressed on PV interneurons in primate dlPFC; beta1-AR agonist has mixed effects on fast-spiking neuron firing during working memory, and beta1-AR antagonism prevents stress-induced working memory deficits",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.ynstr.2024.100628",
    "claim": "Beta1-adrenoceptors are expressed on PV interneurons in primate dlPFC; beta1-AR agonist has mixed effects on fast-spiking neuron firing during working memory, and beta1-AR antagonism prevents stress-induced working memory deficits",
    "evidence": "Beta1-adrenoceptors are expressed on PV interneurons in primate dlPFC; beta1-AR agonist has mixed effects on fast-spiking neuron firing during working memory, and beta1-AR antagonism prevents stress-induced working memory deficits",
    "effect_size": "Beta1-adrenoceptors are expressed on PV interneurons in primate dlPFC; beta1-AR agonist has mixed effects on fast-spiking neuron firing during working memory, and beta1-AR antagonism prevents stress-i",
    "text_access": "fulltext",
    "study_system": "macaque dorsolateral prefrontal cortex, in vivo iontophoresis",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "PV interneurons can be identified as fast-spiking (FS) in physiological recordings, and thus were studied in macaques performing a working memory task. Iontophoresis of a β1-AR agonist had a mixed effect, increasing the firing of a subset and decreasing the firing of others, likely reflecting loss of firing of the entire microcircuit.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "PV interneurons can be identified as fast-spiking (FS) in physiological recordings, and thus were studied in macaques performing a working memory task. Iontophoresis of a β1-AR agonist had a mixed effect, increasing the firing of a subset and decreasing the firing of others, likely reflecting loss of firing of the entire microcircuit."
  },
  "section_id": "section_09_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "effect_size": "Beta1-adrenoceptors are expressed on PV interneurons in primate dlPFC; beta1-AR agonist has mixed effects on fast-spiking neuron firing during working memory, and beta1-AR antagonism prevents stress-i",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-09",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-fff3aaa31d0b"
  ],
  "source_span": "PV interneurons can be identified as fast-spiking (FS) in physiological recordings, and thus were studied in macaques performing a working memory task. Iontophoresis of a β1-AR agonist had a mixed effect, increasing the firing of a subset and decreasing the firing of others, likely reflecting loss of firing of the entire microcircuit.",
  "study_system": "macaque dorsolateral prefrontal cortex, in vivo iontophoresis",
  "evidence_refs": [
    {
      "ref": "paper:paper-fff3aaa31d0b"
    }
  ],
  "section_title": "Brain Region and Layer Context: Beyond Primary Sensory Cortex",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Beta1-adrenoceptors are expressed on PV interneurons in primate dlPFC; beta1-AR agonist has mixed effects on fast-spiking neuron firing during working memory, and beta1-AR antagonism prevents stress-induced working memory deficits",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-09",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}