Version history

{
  "scope": "Mouse V1, awake behaving; 2P holographic optogenetics + imaging + detection task",
  "claim_text": "In mouse V1, the behavioral effect of holographically activating a small ensemble is best predicted by the ensemble's recurrent network influence (effect on local activity), not by the visual selectivity of the activated cells — direct causal evidence that recurrent E→E network coupling, not feedforward labels, governs perceptual readout.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2025.04.023",
    "claim": "In mouse V1, the behavioral effect of holographically activating a small ensemble is best predicted by the ensemble's recurrent network influence (effect on local activity), not by the visual selectivity of the activated cells — direct causal evidence that recurrent E→E network coupling, not feedforward labels, governs perceptual readout.",
    "cite_key": "Bounds2025",
    "evidence": "Two-photon imaging combined with cellular-resolution holographic optogenetic photostimulation in awake mice performing a visual detection task; ensembles selected by visual selectivity vs randomly.",
    "effect_size": "targeted activation of visually sensitive ensembles did NOT preferentially modify behavior versus random ensembles (qualitative)",
    "text_access": "abstract_only",
    "study_system": "Mouse V1, awake behaving; 2P holographic optogenetics + imaging + detection task",
    "argument_role": "supporting",
    "replication_status": "within_lab",
    "claim_source_sentence": "Instead, an activated ensemble's effect on local network activity was the main predictor of its impact on perception.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Contrary to expectations, targeted activation of visually sensitive neural ensembles did not preferentially modify behavior compared with targeting randomly selected ensembles."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "targeted activation of visually sensitive ensembles did NOT preferentially modify behavior versus random ensembles (qualitative)",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-98da70ca1cdd"
  ],
  "source_span": "Instead, an activated ensemble's effect on local network activity was the main predictor of its impact on perception.",
  "study_system": "Mouse V1, awake behaving; 2P holographic optogenetics + imaging + detection task",
  "evidence_refs": [
    {
      "ref": "paper:paper-98da70ca1cdd"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon imaging combined with cellular-resolution holographic optogenetic photostimulation in awake mice performing a visual detection task; ensembles selected by visual selectivity vs randomly.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "within_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}